Comparison of urinary glucose excretion with SGLT2 inhibitors
| Study | Dose (mean 24-h urinary glucose excretion) | Dose response |
|---|---|---|
| Empagliflozin | ||
| Zhao et al.9 | Day 1: 10 mg (88 g), 25 mg (83 g) Day 9: 10 mg (96 g), 25 mg (83 g) | No difference between 10-mg and 25-mg doses |
| Kanada et al.10 | Day 1: 1 mg (40 g), 5 mg (80 g),10 mg (85 g), 25 mg (90 g) Day 27: 1 mg (41 g), 5 mg (77 g), 10 mg (81 g), 25 mg (93 g) (estimated from chart) | Dose response |
| Scheen11 | Day 1: 0.5 mg (5 g), 2.5 mg (30 g), 10 mg (50 g), 25 mg (58 g), 50 mg (64 g), 100 mg (80 g), 200 mg (69 g), 400 mg (90.8 g), 800 mg (62 g) (estimated from chart) | Dose response up to about 100-mg dose |
| Product monograph | 10 mg (64 g), 25 mg (78 g) | Dose response |
| Heise et al.12 | Day 1: 10 mg (74 g), 25 mg (90 g), 100 mg (81 g) | Dose response up to 25-mg dose |
| Dapagliflozin | ||
| Parkinson et al.13 | 2.5 mg (37.9 g), 5 mg (45.2 g), 10 mg (86.4 g) | Dose response |
| Yang et al.14 | Day 10: 5 mg (28 g), 10 mg (41 g) | Dose response |
| Product monograph | 10 mg (~70 g); urinary glucose excretion approached a maximum at 20-mg dose | Dose response up to 20-mg dose |
| Canagliflozin | ||
| Iijima et al.15 | Ranged from 80 to 110 g; smallest at 25-mg dose, no great difference at 100- to 400-mg dose | Dose response up to 100-mg dose |
| Devineni and Polidori16 | 100–300 mg (ranged from 80 to 120 g) | Dose response |
| Product monograph | 100–300 mg (ranged from 77 to 119 g) | Not clear |
| Devineni et al.17 | 50 mg, 100 mg, 300 mg (increased in a dose-dependent manner) | Dose response |
| Remogliflozin | ||
| Kapur et al.18 | 20 mg (67 mmol), 50 mg (97 mmol), 150 mg (168 mmol), 500 mg (223 mmol), 1000 mg (304 mmol) | Dose response |
| Dobbins et al.19 | 200 mg (509 mmol), 1000 mg (918 mmol), 2000 mg (574 mmol) | Dose response up to 1000-mg dose |
| Ipragliflozin | ||
| Veltcamp et al.20 | Dose response was noted up to the 50- or 100-mg dose; actual change in urinary glucose excretion depended on the study (50 g in one study and 80–90 g in another study) | Dose response up to 50-mg dose |
| Kadokura et al.21 | 50 mg (80.6 g ± 22.2 g), 100 mg (89.7 ± 12.3 g) | No difference between 50-mg and 100-mg dose |
| Ertugliflozin | ||
| Amin et al.22 | 1 mg (46.33 g), 5 mg (64.54 g), 25 mg (74.49 g) | Dose response |
| Tofogliflozin | ||
| Ikeda et al.23 | 2.5 mg (217.9 mmol), 5 mg (272.3 mmol), 10 mg (346.2 mmol), 20 mg (396.0 mmol), 40 mg (402.9 mmol) | Dose response |
| Sotogliflozin | ||
| Zambrowicz et al.24 | 400 mg (29.7 g) | Not clear |
| Rosenstock et al.25 | 75 mg (~18 g), 200 mg (~66 g), 400 mg (55–60 g) (estimated from chart) | Dose response up to 200-mg dose |
Note: SD = standard deviation, SGLT2 = sodium glucose cotransporter-2.