Presence of advanced melanoma (> 2.0 mm thickness) according to study factors, for the overall cohort and stratified by ulceration status
| Characteristic | Presence of advanced melanoma (> 2.0 mm thickness)* | p value† | ||
|---|---|---|---|---|
| Overall (n = 8042) | Ulceration absent (n = 6581) | Ulceration present (n = 1461) | ||
| No. of patients with advanced melanoma (%) | 2069 (25.7) | 929 (14.1) | 1140 (78.0) | |
| Patient factors | ||||
| Sex, % | Overall: p < 0.001 | |||
| Male | 29.6 | 15.8 | 79.7 | Abs v. pres: p < 0.001 |
| Female | 21.4 | 12.3 | 75.1 | |
| Age | Overall: p < 0.001 | |||
| Median age, yr (mean)‡ | 69 (67.16) | 67 (65.9) | 71 (68.2) | Abs v. pres: p < 0.001 |
| Age group. % | ||||
| 20–45 yr | 15.0 | 8.2 | 71.1 | |
| 46–55 yr | 19.4 | 11.0 | 73.9 | |
| 56–65 yr | 22.4 | 13.1 | 72.3 | |
| 66–75 yr | 27.0 | 14.9 | 75.9 | |
| 76–85 yr | 37.1 | 20.9 | 83.5 | |
| >85 yr | 53.2 | 31.5 | 91.1 | |
| Material deprivation, % | Overall: p < 0.001 | |||
| Least deprived | 22.9 | 12.8 | 75.2 | Abs v. pres: p < 0.001 |
| Quintile 2 | 25.3 | 12.9 | 78.5 | |
| Quintile 3 | 28.3 | 16.2 | 78.3 | |
| Quintile 4 | 30.0 | 17.8 | 77.4 | |
| Most deprived | 35.1 | 19.8 | 83.8 | |
| Data missing | 8.8 | 3.8 | 75.0 | |
| Health-system factors | ||||
| LHIN, % | Overall: p < 0.001 | |||
| LHIN A | 21.3 | 11.3 | 77.5 | Abs v. pres: p < 0.001 |
| LHIN B | 22.7 | 13.5 | 80.0 | |
| LHIN C | 23.4 | 13.5 | 72.4 | |
| LHIN D | 23.9 | 9.1 | 75.3 | |
| LHIN E | 24.3 | 14.2 | 80.8 | |
| LHIN F | 24.7 | 13.8 | 77.2 | |
| LHIN G | 25.4 | 15.2 | 70.1 | |
| LHIN H | 25.5 | 12.8 | 80.4 | |
| LHIN I | 26.8 | 13.6 | 76.9 | |
| LHIN J | 26.9 | § | § | |
| LHIN K | 27.1 | 15.7 | 76.0 | |
| LHIN L | 29.2 | 15.1 | 78.5 | |
| LHIN M | 31.2 | 19.4 | 83.3 | |
| LHIN N | 31.7 | § | § | |
| Rurality | Overall: p < 0.001 | |||
| Median rurality (mean)‡ | 5.0 (13.4) | 5.0 (13.3) | 5.0 (13.5) | Abs v. pres: p < 0.001 |
| Rural (≥40), % | 27.8 | 16.0 | 78.1 | |
| Non-major urban (9.01–39), % | 25.7 | 14.5 | 76.7 | |
| Major urban (0–9), % | 27.2 | 14.9 | 78.6 | |
| Data missing, % | 9.2 | 4.1 | 77.1 | |
| Disease factors | ||||
| Histological subtype, % | Overall: p < 0.001 | |||
| Superficial spreading | 13.6 | 8.0 | 61.9 | Abs v. pres: p < 0.001 |
| Lentigo maligna | 9.3 | 6.5 | 52.5 | |
| Acral lentiginous | 51.2 | 23.0 | 87.7 | |
| Nodular | 77.9 | 63.0 | 90.2 | |
| NOS | 18.9 | 10.6 | 72.8 | |
| Other | 54.7 | 42.3 | 86.2 | |
| Body site, % | Overall: p < 0.001 | |||
| Extremities | 24.6 | 13.2 | 77.7 | Abs v. pres: p < 0.001 |
| Face | 25.5 | 15.4 | 74.3 | |
| Head and neck | 38.9 | 24.0 | 84.8 | |
| Trunk | 24.2 | 12.8 | 80.3 | |
| Unspecified | 33.8 | 19.3 | 78.0 | |
| Presence of ulceration, % | Overall: p < 0.001 | |||
| Present | 78.0 | – | – | – |
| Absent | 14.1 | – | – | – |
| Lymph node involvement, % | Overall: p < 0.001 | |||
| Present | 73.4 | 54.5 | 90.5 | Abs v. pres: p < 0.001 |
| Absent | 20.4 | 11.6 | 73.0 | |
| Distant metastases, % | Overall: p < 0.001 | |||
| Present | 61.5 | 38.0 | 87.0 | Abs v. pres: p < 0.001 |
| Absent | 25.3 | 13.9 | 77.7 | |
Note: Abs = absent, LHIN = local health integration network; pres = present.
↵* Percentages are calculated as 100% minus the percentage of patients with the same characteristic who had non-advanced melanoma.
↵† p values based on χ2 test.
↵‡ Values shown for median and mean are for the subset with advanced melanoma.
↵§ Censored because of small cell counts.