| Scenario* | Modelled overall health care system cost, $ | Modelled life-years | Modelled QALYs | Health care system incremental cost, $ | Incremental cost-effectiveness ratio, $/life-year | Incremental cost-utility ratio, $/QALY |
|---|---|---|---|---|---|---|
| Increasing | ||||||
| Biennial 50-74 yr | 4 217 275 | 30 669 | 25 053 | |||
| Annual 50-69 yr | 5 250 458 | 30 688 | 25 069 | 1 033 183 | 54 862 | 62 549 |
| Annual 50-74 yr | 5 789 126 | 30 694 | 25 075 | Weakly dominated | ||
| Annual 40-49 yr, biennial 50-69 yr | 6 072 758 | 30 697 | 25 078 | Weakly dominated | ||
| Annual 40-49 yr; biennial 50-74 yr | 6 444 999 | 30 703 | 25 083 | Weakly dominated | ||
| Annual 40-69 yr | 7 516 630 | 30 721 | 25 098 | 2 266 172 | 68 184 | 79 266 |
| Annual 40-74 yr | 8 051 766 | 30 727 | 25 103 | 535 136 | 88 088 | 110 994 |
| Decreasing | ||||||
| Biennial 50-74 yr | 4 217 275 | 30 669 | 25 053 | |||
| Biennial 50-69 yr | 3 835 726 | 30 662 | 25 048 | 381 549 | 61 296 | 77 307.62 |
| Triennial 50-74 yr | 3 642 494 | 30 653 | 25 039 | Weakly dominated | Weakly dominated | |
| Triennial 50-69 yr | 3 368 225 | 30 648 | 25 036 | 467 501 | 31 958 | 38 142 |
| No screening | 1 965 899 | 30 602 | 24 998 | 1 402 326 | 30 536 | 36 981 |
Note: QALY = quality-adjusted life-year.
*Increasing = scenarios in which screening is increased from baseline; decreasing = scenarios in which screening is decreased from baseline. Incremental cost-effectiveness ratios and cost-utility ratios express dollars saved per life-year or QALY lost.