Table 6: Scenario C: cost-effectiveness of palivizumab prophylaxis versus no prophylaxis in healthy term infants who were less than 6 months of age at the start of the 2009 RSV season or were born during the season per RSV-related hospital admission avoided, with 88% risk reduction and 15% palivizumab wastage
VariableNorthwest TerritoriesNunavutNunavut without IqaluitKitikmeotKivalliqQikiqtaalukQikiqtaaluk without IqaluitNunavik
Total births in 2009739816701114245457342250
Healthy newborns679.9750.7644.9104.9225.4420.4314.6230
Estimated rate of RSV-related admissions per 1000 population at risk†16.697.8111.6296.1112.740.349.4184.1
Base case: no prophylaxis, RSV-related admissions in healthy term infants
Total no. of RSV-related admissions documented in 2009 in healthy term infants852512218121130
Total cost of admissions, $177 2562 871 1372 856 5611 496 3651 094 603280 169265 593632 139
Scenario C: universal palivizumab prophylaxis of healthy term infants, with 88% risk reduction
Total no. of RSV-related admissions0.966.246.122.642.161.441.323.6
Total costs of RSV-related admissions, $21 271344 536342 787179 564131 35233 62031 87175 857
Estimated cost of palivizumab, $5 009 1705 653 8594 874 975840 4271 708 2853 105 1482 326 2641 720 849
Total costs (palivizumab + RSV-related admissions), $5 030 4415 998 3955 217 7621 019 9911 839 6373 138 7682 358 1351 796 706
Scenario C v. base case
Incremental cost for RSV prophylaxis, $4 853 1853 127 2592 361 202-476 374745 0352 858 5992 092 5421 164 566
Incremental RSV-related admissions avoided7.045.844.919.415.810.69.726.4
ICER per RSV-related admission avoided, $714 58069 08752 898-26 87747 201277 275221 72444 976
NNT to prevent 1 RSV-related admission77.213.111.54.311.431.826.07.0

Note: ICER = incremental cost-effectiveness ratio, NNT = number needed to treat, RSV = respiratory syncytial virus.