Table 4: Neuron-specific enolase serum level cut-off values, sensitivity and specificity from included studies, by outcome

Outcome	Cut-off values (µg/L)	Sensitivity (%)	Specificity (%)
Mortality
Yamazaki et al.⁵⁶	20	100	73
Vos et al.⁵³	21.7	85	48
Olivecrona et al.⁴⁵	11.6	100	45
Chabok et al.³³	51.8	100	100
Zhang et al.⁵⁹	17.6	93	62
Glasgow Outcome Scale ≤ 3
Raabe et al.⁴⁸	100	9	96
Guan et al.³⁸	60	54	96
Zhan et al.⁵⁸	30	67	83
Li et al.⁴⁰	30	67	77
Vos et al.⁵³	21.7	80	55
Olivecrona et al.⁴⁵	9.5	87	36
Meric et al.⁴⁴	20.5	87	82
Zhang et al.⁵⁹	16.4	87	82