Table 2: Motivation for research efforts reported by authors aware of existing RCT evidence
RCT-related motivationNo. (%) studies
Studies with only 1 
RCT-related motivation
n = 125
All studies*
n = 213
Assess effects in the "real world"41 (32.8)80 (37.6)
Assess different outcomes34 (27.2)68 (31.9)
RCT evidence inconclusive or inconsistent23 (18.4)55 (25.8)
   Compared with randomized evidence6 (4.8)15 (7.0)
   Compared with randomized and nonrandomized evidence17 (13.6)40 (18.8)
Study specific patient population20 (16.0)50 (23.5)
Other7 (5.6)21 (9.9)
None-19 (8.9)

Note: RCT = randomized control trial.

*For study details, see Appendix 4 (available at www.cmajopen.ca/content/4/2/E132/suppl/DC1).