Table 1: Characteristics of the included studies
StudyNo. of participantsInterventionFollow-up
de Jager et al.26N = 271
Intervention: n =138
Control: n = 133		Daily dose of TrioBe Plus W containing folic acid (0.8 mg), cyanocobalamin (0.5 mg) and pyridoxine HCl (20 mg) for 24 moImmediate postintervention
Doody et al.24N = 821
Intervention: n = 409
Control: n = 41		Donepezil (5 mg/day for 6 wk, 10 mg/day for 42 wk); total duration of interview was 48 wkImmediate postintervention
Feldman et al.16N = 1018
Intervention: n = 508
Control: n = 510		Rivastigmine (3-12 mg daily) for up to 48 moImmediate postintervention
Lee et al.22N = 36
Intervention: n = 18
Control: n = 18		Three 1-g soft gelatine capsules each day, each containing docosahexaenoic acid (DHA, 430 mg) and eicosapentaenoic acid (EPA, 150 mg); total dosage for the fish oil group was about 1.3 g DHA and 0.45 mg EPA daily for 12 moImmediate postintervention
Naeini et al.23N = 256
Intervention: n = 127
Control: n = 129		Vitamin E (300 mg daily) plus vitamin C (400 mg daily) for 12 moImmediate postintervention
Petersen et al.27N=769
Intervention 1: n = 253
Intervention 2: n = 257
Control: n = 259		Intervention 1 (donepezil, placebo Vitamin E and multivitamin): initial dose of 5 mg daily; increased to 10 mg daily after 6 wk for 36 mo
Intervention 2 (vitamin E, placebo donepezil, multivitamin): initial dose of vitamin E of 1000 IU daily; increased to 2000 IU daily after 6 wk for 36 mo		Immediate postintervention
Rojas et al.21N = 46
Intervention: n = 24
Control: n = 22		Cognitive stimulation training sessions and cognitive training delivered by two experienced neurophysiologists in 2 weekly group (4-5 participants) sessions of 120 min at hospital-based outpatient memory clinics over 6 mo6 mo
Suzuki et al.18N = 50
Intervention: n = 25
Control: n = 25		Multicomponent exercise group under the supervision of physiotherapists for 90 min/d, 2 d/wk, for a total of 80 times over 12 moImmediate postintervention
Suzuki et al.25N = 100
Intervention: n = 50
Control: n = 50		Six-month, multicomponent exercise program including biweekly 90-min sessions involving aerobic exercise, muscle strength training, postural balance retraining, and dual-task training, and focus on promoting exercise and behaviour changeImmediate postintervention
Tsolaki et al.19N = 196
Intervention: n =1 22
Control: n = 79		Therapeutic Techniques of nPhTh: holistic approach including cognitive training, cognitive stimulation and psychotherapeutic techniques for 6 moImmediate postintervention
Wei et al.20N = 60
Intervention: n = 30
Control: n = 30		Two groups (15 participants per group) exercised under the supervision of trained nurses for 30 min/d, 5 d/wk, for a total of 120 times over 6 moImmediate postintervention
Winblad et al.17Study 1: N = 990
Intervention: n = 494
Control: n = 496
Study 2: N = 1058
Intervention: n = 532
Control: n = 526		Galantamine was administered at 4 mg twice daily for 1 mo, then 8 mg twice daily for 1 mo; If well-tolerated, the dosage would be titrated to 12 mg twice daily but would be lowered back to 8 mg twice daily after 1 mo if necessary; the dosage selected at month 3 (8 or 12 mg twice daily) was fixed for the remainder of the 24-mo studyImmediate postintervention