| Outcome; intervention type | Effect | Statistical heterogeneity (within-group), p value (I2 value, %) | No. of participants | No. of studies | Quality of evidence rating* | ||
|---|---|---|---|---|---|---|---|
| RR (95% CI) | Absolute risk reduction, % | Number needed to treat (95% CI) | |||||
| Maintenance of loss of ≥ 5% baseline body weight | |||||||
| Pharmacological + behavioural | 1.33 (1.15–1.54) | 12.37 | 8 (5–18) | 0.31 (14) | 987 | 3 | Moderate |
| Maintenance of loss of ≥ 10% baseline body weight | |||||||
| Pharmacological + behavioural | 1.76 (0.75–4.12) | — | — | 0.01 (85) | 731 | 2 | Low |
Note: RR = risk ratio. *Grading of Recommendations Assessment, Development and Evaluation (GRADE) quality of evidence rating reflects confidence in the estimate of effect assessed through 5 domains of the evidence (risk of bias, indirectness, imprecision, inconsistency and reporting bias): moderate = downgraded for risk of bias, low = downgraded for risk of bias and imprecision.