Table 2: Assessment of the studies that tested the high-sensitivity troponin T assay or high-sensitivity troponin I assay for risk of bias using the Quality Assessment of Diagnostic Accuracy Studies tool8
StudyRepresentative spectrum?Acceptable reference standard?Acceptable delay between tests?Partial verification avoided?Differential verification avoided?Incorporation avoided?Reference standard results blinded?Index test results blinded?Uninterpretable results reported?Withdrawals explained?Sponsoring precluded?
Troponin T
Reichlin et al. 20099YesYesYesYesYesYesYesYesNoYesYes
Christ et al. 201010YesYesYesYesYesYesUnclearUnclearYesYesYes
Aldous et al. 201111NoYesYesYesYesYesNoYesYesYesYes
Body et al. 201112YesYesYesYesYesYesUnclearYesYesYesNo
Freund et al. 201113YesYesYesYesYesYesUnclearYesYesYesUnclear
Melki et al. 201114YesYesYesYesYesYesYesYesYesYesUnclear
Reiter et al. 201115YesYesYesYesYesYesYesYesYesYesYes
Weber et al. 201116YesYesYesYesYesYesUnclearYesYesUnclearUnclear
Aldous et al. 201217YesYesYesYesYesYesUnclearYesYesYesUnclear
Troponin I
Reichlin et al. 20099YesYesYesYesYesYesYesYesNoYesYes
Keller et al. 200924YesYesYesYesYesYesUnclearYesYesYesUnclear
Bhardwaj et al. 201123YesYesUnclearYesYesYesUnclearYesYesYesYes

Note: Yes = high quality, No = low quality. Weighted κ = 0.70, 95% confidence interval 0.54–0.87, p < 0.001 (indicates substantial agreement according to Koch and Landis).18,19