Table 5: Diagnostic performance of high-sensitivity troponin I versus conventional troponin T assay at presentation

Study	High-sensitivity troponin I assay					Conventional troponin T assay
Study	Cut-off point and assay	Sensitivity	Specificity	NPV, %	PPV, %	Cut-off point and assay	Sensitivity	Specificity	NPV, %	PPV, %
Reichlin et al. 2009⁹	40 ng/L ADVIA Centaur Immunoassay System (Siemens)	0.89	0.92	98	68	0.035 ng/mL 4th generation (Roche)	0.72	0.97	94	85
Bhardwaj et al. 2011²³	6.28 ng/L Erenna Immunoassay System (Singulex)	0.57	0.86	89	50	0.03 ng/mL Elecsys 2010 or E170 platforms (Roche Diagnostics)	0.22	0.97	84	65
Keller et al. 2009²⁴	40 ng/L Troponin I Ultra (Siemens Healthcare Diagnostics)	0.91	0.90	96.4	76.7	0.03 ng/mL (Roche)	0.64	0.97	88.3	88.8

Note: NPV = negative predictive value, PPV = positive predictive value.