Table 4: Diagnostic performance of high-sensitivity troponin T compared with conventional troponin assay at various times after presentation
StudyDiagnostic performance using serial high-sensitivity troponin T assays
Early assay, AUC (95% CI)Later assay, AUC (95% CI)
Reichlin et al. 200993 h from presentation:
0.98 (0.97–0.99)		6 h from presentation:
0.98 (0.96–0.99)
Reiter et al. 2011*153 h from presentation:
0.97 ( 0.94–0.99)		6 h from presentation:
0.96 (0.92–0.99)
Christ et al. 201010NANA
Aldous et al. 201111NA6–24 h from presentation:
0.94 (0.91–0.97)
Body et al. 201112NANA
Freund et al. 201113NANA
Weber et al. 201116NANA
Melki et al. 2011142 h from presentation:
sensitivity 0.99, specificity 0.71
PPV 77%, NPV 99%		NA
Aldous et al. 2012172 h from presentation:
sensitivity 0.92, specificity 0.80
PPV 55.9%, NPV 97.3%		NA

Note: AUC = area under the curve, CI = confidence interval, NA = not available, NPV = negative predictive value, PPV = positive predictive value.
*Older population (≥ 70 yr).