| Patient no. | Year | Sex | Age, yr | Diagnosis | Course of occurrence* | Interval to diagnosis, days† | Nadir ANC (× 109/L) | Biopsy site‡ | Galactomannan antigen test (index value)§ | Organism cultured | PPx | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Proven | ||||||||||||
| 1 | 2008 | F | 66 | AML | 1 | 19 | 0 | Skin | Serum: > 6.4 | Aspergillus fumigatus | Fl | Died |
| 2 | 2009 | M | 53 | AML | 1 | 19 | 0 | Lung | Serum: 3.0 Lavage: 3.0 | Aspergillus terreus | Fl | Died |
| 3 | 2010 | F | 57 | ALL | 2 | 11 | 1.4 | Lung | Serum: < 0.5 Lavage: < 2.0 | No growth | C | Survived |
| Probable | ||||||||||||
| 4 | 2009 | M | 56 | AML | 1 | 11 | 0 | NA | Serum: < 0.5 Lavage: 3.5 | No growth | Fl | Died |
| 5 | 2009 | F | 40 | ALL | 2 | 28 | 0 | NA | Serum: < 0.5 Lavage: 6.9 | Aspergillus sp. | C | Survived |
| 6 | 2009 | M | 57 | AML | 1 | 24 | 0 | NA | Serum: < 0.5 Lavage: 5.8 | Aspergillus nidulans | C | Survived |
| 7 | 2010 | M | 38 | AML | 1 | 19 | 0 | NA | Serum: < 0.5 Lavage: 4.9 | No growth | Fl | Survived |
| 8 | 2010 | F | 65 | AML | 1 | 17 | 0 | NA | Serum: 4.4 Lavage: < 2.0 | No growth | Fl | Died |
| 9 | 2010 | F | 58 | AML | 1 | 34 | 0 | NA | Serum: 5.9 Lavage: 3.0 | No growth | Fl | Survived |
Note: ALL = acute lymphocytic leukemia, AML = acute myeloid leukemia, ANC = absolute neutrophil count, C = caspofungin, Fl = fluconazole, NA = not applicable, PPx = prophylaxis. *Course of remission–induction chemotherapy during which invasive aspergillosis occurred. †Number of days from initiation of chemotherapy until diagnosis of invasive aspergillosis. ‡Histopathology results compatible with invasive aspergillosis (hyphae-associated tissue damage). §”Lavage” refers to fluid from bronchoalveolar lavage. Index value refers to optical density. Values < 0.5 for serum and < 2.0 for lavage fluid are considered negative.