Table 3: Cost estimates for active surveillance and immediate treatment over the first year and 5 to 10 years of follow-up

Period of follow-up; strategy	%			Mean cost per patient (95% CI)†, $	Cost difference (immediate treatment v. active surveillance)
Period of follow-up; strategy	Mortality*	Recurrence*	Discount*	Mean cost per patient (95% CI)†, $	Absolute, $	Relative, %
First year and 5-year follow-up
Active surveillance	3.8	13.9	—	6 200 (6 083–6 317)	7 535	54.9
Active surveillance	3.8	13.9	5	5 515 (5 413–5 619)	7 551	57.8
Immediate treatment	3.8	2.57	—	13 735 (13 615–13 855)
Immediate treatment	3.8	2.57	5	13 166 (12 966–13 165)
First year and 10-year follow-up
Active surveillance	3.8	13.9	—	10 600 (10 377–10 822)	7 808	42.4
Active surveillance	3.8	13.9	5	8 484 (8 313–8 654)	7 755	47.8
Immediate treatment	3.8	2.57	—	18 408 (18 162–18 653)
Immediate treatment	3.8	2.57	5	16 239 (16 060–16 418)

Note: CI = confidence interval. *Yearly rate. †The 95% CI of the mean cost was obtained by the simulation of 1000 samples of equal sample size of 12 750 patients.