| Canada | United Kingdom (5) | |||||
|---|---|---|---|---|---|---|
| Variable | Baseline | Optimistic | Pessimistic | Baseline | Optimistic | Pessimistic |
| Input parameter estimates | ||||||
| Time lag, yr | 13 | 10 | 17 | 17 | 10 | 25 |
| QALY value | $50 000 | $60 000 | $40 000 | $25 000 | $30 000 | $20 000 |
| National contribution, % | 6 | 8 | 4 | 17 | 25 | 10 |
| Medical research contribution, % | 70 | 100 | 50 | 100 | 100 | 100 |
| Estimated research expenditure, % | 100 | 100 | 125 | Central | Low | High |
| Internal rate of return estimates, % | ||||||
| Point time lag case | 20.6 | 35.1 | 10.3 | 9.2 | 22.5 | Negative |
| Distribution time lag case | 20.6 | 35.0 | 10.0 | NA | NA | NA |
Note: NA = not available, QALY = quality-adjusted life-years.