Table 2: Estimates of the input parameters and the internal rate of return for Canada and the United Kingdom
CanadaUnited Kingdom5
VariableBaselineOptimisticPessimisticBaselineOptimisticPessimistic
Input parameter estimates
Time lag, yr131017171025
QALY value$50 000$60 000$40 000$25 000$30 000$20 000
National contribution, %684172510
Medical research contribution, %7010050100100100
Estimated research expenditure, %100100125CentralLowHigh
Internal rate of return estimates, %
Point time lag case20.635.110.39.222.5Negative
Distribution time lag case20.635.010.0NANANA

Note: NA = not available, QALY = quality-adjusted life-years.