| Metabolite, institutional units | Treatment group; mean ± SD | p value | |
|---|---|---|---|
| Patients with mitochondrial disorders | Controls | ||
| Caudate nucleus | |||
| NAA | 7.04 ± 1.19 | 8.19 ± 1.18 | 0.02 |
| Cr | 6.84 ± 1.42 | 7.52 ± 0.76 | 0.03 |
| GPC | 1.77 ± 0.47 | 1.88 ± 0.21 | 0.052 |
| GPC and PCh | 1.77 ± 0.47 | 1.89 ± 0.19 | 0.04 |
| MI | 4.47 ± 1.83 | 4.13 ± 0.81 | 0.96 |
| Glx | 12.81 ± 2.38 | 14.87 ± 1.98 | 0.02 |
| Anterior cingulate cortex | |||
| NAA | 8.20 ± 1.53 | 8.20 ± 1.04 | 0.99 |
| Cr | 7.81 ± 1.32 | 7.10 ± 0.99 | 0.1 |
| GPC | 2.56 ± 0.51 | 2.40 ± 0.40 | 0.4 |
| GPC and PCh | 2.56 ± 0.51 | 2.40 ± 0.37 | 0.3 |
| MI | 6.20 ± 1.55 | 5.65 ± 1.74 | 0.4 |
| Glx | 17.18 ± 3.17 | 16.47 ± 2.94 | 0.54 |
| Hippocampus | |||
| NAA | 8.65 ± 1.85 | 8.88 ± 1.33 | 0.7 |
| Cr | 6.82 ± 1.27 | 6.94 ± 1.12 | 0.8 |
| GPC | 2.32 ± 0.49 | 2.48 ± 0.53 | 0.4 |
| GPC and PCh | 2.32 ± 0.49 | 2.48 ± 0.53 | 0.4 |
| MI | 5.60 ± 1.30 | 5.91 ± 1.54 | 0.9 |
| Glx | 12.49 ± 3.03 | 12.55 ± 3.14 | 0.96 |
Note: Cr = creatine, Glx = glutamine and glutamate, GPC = glycerophosphocholine, MI = myo-inositol, NAA = N-acetyl-aspartate, PCh = phosphocholine, SD = standard deviation.