RT Journal Article
SR Electronic
T1 Association between the COVID-19 pandemic and first cancer treatment modality: a population-based cohort study
JF CMAJ Open
JO CMAJ
FD Canadian Medical Association
SP E426
OP E433
DO 10.9778/cmajo.20220102
VO 11
IS 3
A1 Rui Fu
A1 Rinku Sutradhar
A1 Qing Li
A1 Timothy P. Hanna
A1 Kelvin K.W. Chan
A1 Jonathan C. Irish
A1 Natalie Coburn
A1 Julie Hallet
A1 Anna Dare
A1 Simron Singh
A1 Ambica Parmar
A1 Craig C. Earle
A1 Lauren Lapointe-Shaw
A1 Monika K. Krzyzanowska
A1 Antonio Finelli
A1 Alexander V. Louie
A1 Nicole J. Look Hong
A1 Ian J. Witterick
A1 Alyson Mahar
A1 David R. Urbach
A1 Daniel I. McIsaac
A1 Danny Enepekides
A1 Antoine Eskander
YR 2023
UL http://www.cmajopen.ca/content/11/3/E426.abstract
AB Background: Physicians were directed to prioritize using nonsurgical cancer treatment at the beginning of the COVID-19 pandemic. We sought to quantify the impact of this policy on the modality of first cancer treatment (surgery, chemotherapy, radiotherapy or no treatment).Methods: In this population-based study using Ontario data from linked administrative databases, we identified adults diagnosed with cancer from January 2016 to November 2020 and their first cancer treatment received within 1 year postdiagnosis. Segmented Poisson regressions were applied to each modality to estimate the change in mean 1-year recipient volume per thousand patients (rate) at the start of the pandemic (the week of Mar. 15, 2020) and change in the weekly trend in rate during the pandemic (Mar. 15, 2020, to Nov. 7, 2020) relative to before the pandemic (Jan. 3, 2016, to Mar. 14, 2020).Results: We included 321 535 people diagnosed with cancer. During the first week of the COVID-19 pandemic, the mean rate of receiving upfront surgery over the next year declined by 9% (rate ratio 0.91, 95% confidence interval [CI] 0.88–0.95), and chemotherapy and radiotherapy rates rose by 30% (rate ratio 1.30, 95% CI 1.23–1.36) and 13% (rate ratio 1.13, 95% CI 1.07–1.19), respectively. Subsequently, the 1-year rate of upfront surgery increased at 0.4% for each week (rate ratio 1.004, 95% CI 1.002–1.006), and chemotherapy and radiotherapy rates decreased by 0.9% (rate ratio 0.991, 95% CI 0.989–0.994) and 0.4% (rate ratio 0.996, 95% CI 0.994–0.998), respectively, per week. Rates of each modality resumed to prepandemic levels at 24–31 weeks into the pandemic.Interpretation: An immediate and sustained increase in use of nonsurgical therapy as the first cancer treatment occurred during the first 8 months of the COVID-19 pandemic in Ontario. Further research is needed to understand the consequences.