TY - JOUR T1 - Maternal and neonatal outcomes in pregnancies with type 2 diabetes in First Nation and other Manitoban people: a population-based study JF - CMAJ Open JO - CMAJ SP - E930 LP - E936 DO - 10.9778/cmajo.20220025 VL - 10 IS - 4 AU - Jennifer M. Yamamoto AU - Christy Pylypjuk AU - Elizabeth Sellers AU - Lorraine McLeod AU - Brandy Wicklow AU - Monica Sirski AU - Heather Prior AU - Chelsea Ruth Y1 - 2022/10/01 UR - http://www.cmajopen.ca/content/10/4/E930.abstract N2 - Background: First Nation people living in Canada experience a high prevalence of type 2 diabetes in pregnancy. In this study, we aimed to describe maternal and neonatal outcomes in First Nation and all other females with type 2 diabetes living in Manitoba, Canada.Methods: This was a population-level retrospective cohort study using linked administrative data from Manitoba (2012–2017). We compared First Nation females with type 2 diabetes with all other Manitoban females with type 2 diabetes, using relative risks (RRs) and 95% confidence intervals (CIs).Results: A total of 2181 females with type 2 diabetes were included, and 1218 (55.8%) were First Nation. First Nation females with type 2 diabetes were significantly more likely to experience stillbirth (RR 2.14, 95% CI 1.11–4.13) and perinatal death (RR 2.39, 95% CI 1.37–4.17) than all other Manitoban females with type 2 diabetes. Offspring of First Nation females with type 2 diabetes had a higher risk of most neonatal complications than offspring of all other Manitoban females with type 2 diabetes, including a higher risk of congenital malformations (RR 1.97, 95% CI 1.30–2.99), but First Nation people did not have a higher risk of most maternal complications.Interpretation: First Nation pregnant individuals living with type 2 diabetes experienced a higher risk for adverse pregnancy outcomes than all other Manitoban females with type 2 diabetes. Additional studies are needed to identify both high-risk and protective factors for pregnancy complications in First Nation people living with type 2 diabetes in pregnancy. ER -