TY - JOUR T1 - Cancer incidence attributable to excess body weight in Alberta in 2012 JF - CMAJ Open SP - E330 LP - E336 DO - 10.9778/cmajo.20160039 VL - 5 IS - 2 AU - Darren R. Brenner AU - Abbey E. Poirier AU - Anne Grundy AU - Farah Khandwala AU - Alison McFadden AU - Christine M. Friedenreich Y1 - 2017/04/01 UR - http://www.cmajopen.ca/content/5/2/E330.abstract N2 - Background: Excess body weight has been consistently associated with colorectal, breast, endometrial, esophageal, gall bladder, pancreatic and kidney cancers. The objective of this analysis was to estimate the proportion of total and site-specific cancers attributable to excess body weight in adults in Alberta in 2012.Methods: We estimated the proportions of attributable cancers using population attributable risk. Risk estimates were obtained from recent meta-analyses, and exposure prevalence estimates were obtained from the Canadian Community Health Survey. People with a body mass index of 25.00-29.99 kg/m2 and of 30 kg/m2 or more were categorized as overweight and obese, respectively.Results: About 14%-47% of men and 9%-35% of women in Alberta were classified as either overweight or obese; the proportion increased with increasing age for both sexes. We estimate that roughly 17% and 12% of obesity-related cancers among men and women, respectively, could be attributed to excess body weight in Alberta in 2012. The heaviest absolute burden in terms of number of cases was seen for breast cancer among women and for colorectal cancer among men. Overall, about 5% of all cancers in adults in Alberta in 2012 were estimated to be attributable to excess body weight in 2000-2003.Interpretation: Excess body weight contributes to a substantial proportion of cases of cancers associated with overweight and obesity annually in Alberta. Strategies to improve energy imbalance and reduce the proportion of obese and overweight Albertans may have a notable impact on cancer incidence in the future. ER -