@article {SmolinaE13, author = {Kate Smolina and Steven G. Morgan and Gillian E. Hanley and Tim F. Oberlander and Barbara Mintzes}, title = {Postpartum domperidone use in British Columbia: a retrospective cohort study}, volume = {4}, number = {1}, pages = {E13--E19}, year = {2016}, doi = {10.9778/cmajo.20150067}, publisher = {Canadian Medical Association Open Access Journal}, abstract = {Background: Domperidone is commonly used off-label to stimulate milk production in mothers who have low milk supply. The aim of this study was to describe trends, patterns and determinants of postpartum domperidone use.Methods: This is a retrospective, population-based study involving all women with a live birth between Jan. 1, 2002, and Dec. 31, 2011, in the province of British Columbia. We examined administrative data sets containing person-specific information on filled prescriptions and use of medical services, and we used logistic regression to examine associations between domperidone use and maternal characteristics.Results: The study population consisted of 225 532 women with 320 351 live births. The prevalence of postpartum domperidone use more than doubled between 2002 and 2011. In 2011, 1 in 3 women with a preterm birth and 1 in 5 women with a full-term birth were prescribed domperidone in the first 6 months postpartum. Women who were older, had a higher body mass index, had a chronic disease, were first-time mothers, delivered more than 1 baby (multiple pregnancy), had a preterm birth or had a cesarian delivery were more likely to fill a postpartum domperidone prescription. Interpretation: We found an increase in postpartum domperidone use over a 10-year period. More research is needed on maternal and infant health outcomes.}, URL = {https://www.cmajopen.ca/content/4/1/E13}, eprint = {https://www.cmajopen.ca/content/4/1/E13.full.pdf}, journal = {Canadian Medical Association Open Access Journal} }