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Research

Factors associated with drug shortages in Canada: a retrospective cohort study

Wei Zhang, Daphne P. Guh, Huiying Sun, Larry D. Lynd, Aidan Hollis, Paul Grootendorst and Aslam H. Anis
August 31, 2020 8 (3) E535-E544; DOI: https://doi.org/10.9778/cmajo.20200036
Wei Zhang
Centre for Health Evaluation and Outcome Sciences (Zhang, Guh, Sun, Lynd, Anis), St. Paul’s Hospital; School of Population and Public Health (Zhang, Anis) and Faculty of Pharmaceutical Sciences (Lynd), University of British Columbia, Vancouver, BC; Department of Economics (Hollis), University of Calgary, Calgary, Alta.; Leslie Dan Faculty of Pharmacy (Grootendorst), University of Toronto, Toronto, Ont.
PhD
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Daphne P. Guh
Centre for Health Evaluation and Outcome Sciences (Zhang, Guh, Sun, Lynd, Anis), St. Paul’s Hospital; School of Population and Public Health (Zhang, Anis) and Faculty of Pharmaceutical Sciences (Lynd), University of British Columbia, Vancouver, BC; Department of Economics (Hollis), University of Calgary, Calgary, Alta.; Leslie Dan Faculty of Pharmacy (Grootendorst), University of Toronto, Toronto, Ont.
MSc
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Huiying Sun
Centre for Health Evaluation and Outcome Sciences (Zhang, Guh, Sun, Lynd, Anis), St. Paul’s Hospital; School of Population and Public Health (Zhang, Anis) and Faculty of Pharmaceutical Sciences (Lynd), University of British Columbia, Vancouver, BC; Department of Economics (Hollis), University of Calgary, Calgary, Alta.; Leslie Dan Faculty of Pharmacy (Grootendorst), University of Toronto, Toronto, Ont.
PhD
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Larry D. Lynd
Centre for Health Evaluation and Outcome Sciences (Zhang, Guh, Sun, Lynd, Anis), St. Paul’s Hospital; School of Population and Public Health (Zhang, Anis) and Faculty of Pharmaceutical Sciences (Lynd), University of British Columbia, Vancouver, BC; Department of Economics (Hollis), University of Calgary, Calgary, Alta.; Leslie Dan Faculty of Pharmacy (Grootendorst), University of Toronto, Toronto, Ont.
PhD
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Aidan Hollis
Centre for Health Evaluation and Outcome Sciences (Zhang, Guh, Sun, Lynd, Anis), St. Paul’s Hospital; School of Population and Public Health (Zhang, Anis) and Faculty of Pharmaceutical Sciences (Lynd), University of British Columbia, Vancouver, BC; Department of Economics (Hollis), University of Calgary, Calgary, Alta.; Leslie Dan Faculty of Pharmacy (Grootendorst), University of Toronto, Toronto, Ont.
PhD
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Paul Grootendorst
Centre for Health Evaluation and Outcome Sciences (Zhang, Guh, Sun, Lynd, Anis), St. Paul’s Hospital; School of Population and Public Health (Zhang, Anis) and Faculty of Pharmaceutical Sciences (Lynd), University of British Columbia, Vancouver, BC; Department of Economics (Hollis), University of Calgary, Calgary, Alta.; Leslie Dan Faculty of Pharmacy (Grootendorst), University of Toronto, Toronto, Ont.
PhD
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Aslam H. Anis
Centre for Health Evaluation and Outcome Sciences (Zhang, Guh, Sun, Lynd, Anis), St. Paul’s Hospital; School of Population and Public Health (Zhang, Anis) and Faculty of Pharmaceutical Sciences (Lynd), University of British Columbia, Vancouver, BC; Department of Economics (Hollis), University of Calgary, Calgary, Alta.; Leslie Dan Faculty of Pharmacy (Grootendorst), University of Toronto, Toronto, Ont.
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Online Appendices

Files in this Data Supplement:

  • Appendix 1: Details on the main data sources and study design
  • Original submission
  • Appendix 2: Factors considered in the analyses
  • Appendix 3: Distribution of shortage duration at the DIN level
  • Appendix 4: Basic description of shortages
  • Appendix 5: Pairwise results from the model estimating the association between factors and shortage at the market level
  • Appendix 6: Sensitivity analysis results on the association between factors and shortage at the market level (defined by active ingredients, route and form)
  • Appendix 7: The association between factors and shortage at the DIN level among DINs listed on formularies
  • Reviewer comments
  • STROBE statement

  View article

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