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Extent of a valsartan drug shortage and its effect on antihypertensive drug use in the Canadian population: a national cross-sectional study

Jennifer Fenna, Cherry Chu, Rola Hassan, Tara Gomes and Mina Tadrous
December 07, 2021 9 (4) E1128-E1133; DOI: https://doi.org/10.9778/cmajo.20200232
Jennifer Fenna
Leslie Dan Faculty of Pharmacy (Fenna, Hassan, Gomes, Tadrous), University of Toronto, Toronto, Ont.; Pharmacy Services (Fenna), Alberta Health Services, Edmonton, Alta.; Institute of Health System Solutions and Virtual Care (Chu, Tadrous), Women’s College Hospital; Li Ka Shing Knowledge Institute (Gomes), Unity Health Toronto; Institute of Health Policy, Management and Evaluation (Gomes), University of Toronto, Toronto, Ont.
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Cherry Chu
Leslie Dan Faculty of Pharmacy (Fenna, Hassan, Gomes, Tadrous), University of Toronto, Toronto, Ont.; Pharmacy Services (Fenna), Alberta Health Services, Edmonton, Alta.; Institute of Health System Solutions and Virtual Care (Chu, Tadrous), Women’s College Hospital; Li Ka Shing Knowledge Institute (Gomes), Unity Health Toronto; Institute of Health Policy, Management and Evaluation (Gomes), University of Toronto, Toronto, Ont.
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Rola Hassan
Leslie Dan Faculty of Pharmacy (Fenna, Hassan, Gomes, Tadrous), University of Toronto, Toronto, Ont.; Pharmacy Services (Fenna), Alberta Health Services, Edmonton, Alta.; Institute of Health System Solutions and Virtual Care (Chu, Tadrous), Women’s College Hospital; Li Ka Shing Knowledge Institute (Gomes), Unity Health Toronto; Institute of Health Policy, Management and Evaluation (Gomes), University of Toronto, Toronto, Ont.
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Tara Gomes
Leslie Dan Faculty of Pharmacy (Fenna, Hassan, Gomes, Tadrous), University of Toronto, Toronto, Ont.; Pharmacy Services (Fenna), Alberta Health Services, Edmonton, Alta.; Institute of Health System Solutions and Virtual Care (Chu, Tadrous), Women’s College Hospital; Li Ka Shing Knowledge Institute (Gomes), Unity Health Toronto; Institute of Health Policy, Management and Evaluation (Gomes), University of Toronto, Toronto, Ont.
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Mina Tadrous
Leslie Dan Faculty of Pharmacy (Fenna, Hassan, Gomes, Tadrous), University of Toronto, Toronto, Ont.; Pharmacy Services (Fenna), Alberta Health Services, Edmonton, Alta.; Institute of Health System Solutions and Virtual Care (Chu, Tadrous), Women’s College Hospital; Li Ka Shing Knowledge Institute (Gomes), Unity Health Toronto; Institute of Health Policy, Management and Evaluation (Gomes), University of Toronto, Toronto, Ont.
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    Figure 1:

    Use of valsartan and non-valsartan angiotensin receptor blockers (ARBs) from 2015 to 2019.

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    Figure 2:

    Use of angiotensin receptor blockers (ARBs), angiotensin-converting-enzyme (ACE) inhibitors and other antihypertensives (calcium channel blockers, β-blockers, diuretics) from 2015 to 2019.

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    Table 1:

    Use of antihypertensive drugs before and after the valsartan recall on July 9, 2018

    No. of drugs dispensed (% change)*
    All ARBsValsartanNon-valsartan ARBsACE inhibitorsOther hypertensives†Total
    June 20181 577 509362 2311 215 2781 939 1444 673 7118 190 364
    September 2018‡1 545 591 (−2.0)152 892 (−57.8)1 392 699 (14.6)1 835 269 (−5.4)4 568 105 (−2.3)7 948 965 (−2.9)
    December 2019§1 753 924 (13.5)173 224 (13.3)1 580 700 (13.5)1 976 285 (7.7)5 365 868 (17.5)9 096 077 (14.4)
    • Note: ACE = angiotensin converting enzyme, ARB = angiotensin receptor blockers.

    • ↵* Monthly number of prescriptions dispensed.

    • ↵† Other antihypertensives include calcium channel blockers, β-blockers, diuretics.

    • ↵‡ Percent change from June 2018 to September 2018.

    • ↵§ Percent change from September 2018 to December 2019.

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CMAJ Open: 9 (4)
Vol. 9, Issue 4
1 Oct 2021
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Extent of a valsartan drug shortage and its effect on antihypertensive drug use in the Canadian population: a national cross-sectional study
Jennifer Fenna, Cherry Chu, Rola Hassan, Tara Gomes, Mina Tadrous
Oct 2021, 9 (4) E1128-E1133; DOI: 10.9778/cmajo.20200232

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Extent of a valsartan drug shortage and its effect on antihypertensive drug use in the Canadian population: a national cross-sectional study
Jennifer Fenna, Cherry Chu, Rola Hassan, Tara Gomes, Mina Tadrous
Oct 2021, 9 (4) E1128-E1133; DOI: 10.9778/cmajo.20200232
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