Efficacy of treatment at 90 d post-AIS |
IVT alone strategy, % |
All-cause mortality | 17.86 (13.89-21.82) | β (64.03, 294.50) | 10-14 |
Functional independence | 28.74 (21.80-35.67) | β (46.68, 115.75) | 10-14 |
MT plus IVT strategy |
All-cause mortality, % | 17.86 (13.89-21.82) | β (64.03, 294.50) | 10-14 |
Odds ratio of functional independence, MT plus IVT v. IVT alone* | 2.39 (1.88-3.04) | Log-normal (0.8713, 0.1226) | 10-14 |
Difference in health utility relative to IVT | 0.0735 (0.0137-0.1333) | Normal (0.0735, 0.0305) | 10,12 |
Calibrated monthly transition probabilities of natural history for > 3 mo after stroke | Best fitting parameter set | 1000 convergent parameter sets | |
From functional independence to disability, mo |
4-6 | 0.0321 | - | 17,18,20,21 |
7-12 | 0.0220 | - | 17,18,20,21 |
13-24 | 0.0134 | - | 17,18,20,21 |
25-36 | 0.0111 | - | 17,18,20,21 |
37-48 | 0.0093 | - | 17,18,20,21 |
49-60 | 0.0077 | - | 17,18,20,21 |
From disability to functional independence, mo |
4-6 | 0.0372 | - | 20 |
7-12 | 0.0156 | - | 20 |
13-60 | 0 | - | Assumption** |
From functional independence to death, mo |
4-12 | 0.0080 | - | 17,18,20,21 |
13-24 | 0.0034 | - | 17,18,20,21 |
25-36 | 0.0039 | - | 17,18,20,21 |
37-48 | 0.0043 | - | 17,18,20,21 |
49-60 | 0.0047 | - | 17,18,20,21 |
From disability to death, mo |
4-12 | 0.0229 | - | 17,18,20,21 |
13-24 | 0.0096 | - | 17,18,20,21 |
25-36 | 0.0108 | - | 17,18,20,21 |
37-48 | 0.0122 | - | 17,18,20,21 |
49-60 | 0.0131 | - | 17,18,20,21 |
Health care costs, $CAD† |
First 3 mo after stroke |
Extra cost of MT treatment | 15 000 | γ (25, 600) | 22-28 |
Functional independence (mRS of 0-2) | 18 852 | γ (25, 754.08) | 29 |
Disability (mRS of 3-6) | 57 382 | γ (25, 2295.28) | 29 |
IVT alone, weighted by health status‡ | 46 308 | - | 22-29 |
MT + IVT, weighted by health status§ | 53 471 | - | 22-29 |
Greater than 3 mo after stroke |
Functional independence (mRS of 0-2) | 1 384 per month | γ (25, 55.36) | 29 |
Disability (mRS of 3-5) | 3 080 per month | γ (25, 123.2) | 29 |
Health utility for > 3 mo after stroke |
Functional independence (mRS of 0-2) | 0.71 (0.68-0.74) | β (623.29, 254.58) | 30 |
Disability (mRS of 3-5) | 0.31 (0.29-0.34) | β (407.26, 906.49) | 30 |