Disease burden input |
HBsAg+ prevalence | 2017 | 0.80 (determined) | | 0.29% | 1.6% |
HBsAg+ prevalence (male:female) | 2017 | 1.38 | Kwong et al. 2017 (1) | – | – |
HBeAg+ among HBsAg+ women of child-bearing age | 2012–2016 | 18.9 | WHO 2022 (2) | 9.1% | 24.0% |
Viral load ≥ 20 000 UI/mL among people who are HBeAg+ | 2002–2008 | 90 | WHO 2021 (3) | – | – |
Viral load ≥ 20 000 UI/mL among people who are HBeAg– | 2002–2008 | 13 | WHO 2021 (3) | – | – |
Total diagnosed | 2003–2013 | 39 623* | | – | – |
Newly diagnosed | 2017 | 1878 | Kwong et al. 2017 (1) | – | – |
Total treated | 2018 | 6520† | Kwong et al. 2017, (1) PHAC 2022 (4) | – | – |
Annual liver transplants | 2016 | 264‡ | | – | – |
Liver transplants due to HBV | 2016 | 9.3‡ | | – | – |
HBV vaccination timely birth and 3-dose coverage rates for infants born to HBsAg+ mothers | 2016 | 93.7* | NACI 2021 (5) | – | – |
HBIg coverage rate for infants born to HBsAg+ mothers who also received timely birth dose | 2016 | 93.7* | | – | – |
Economic input |
Disability weight |
Decompensated cirrhosis | 2020 | 0.178 | Biondi et al. 2020 (6) | – | – |
HCC | 2020 | 0.466 | Biondi et al. 2020 (6) | – | – |
Liver transplant | 2020 | 0.024 | Biondi et al. 2020 (6) | – | – |
Value of a statistical life-year, 2020 Can$ |
GDP per capita | 2020 | 62 138 | Coffin et al. 2019 (7) | – | – |
Screening and laboratory cost per test, 2020 Can$ |
HBsAg | 2020 | 10.25§ | | | |
HBeAg | 2020 | 10.25§ | | | |
Viral load testing | 2020 | 100.00* | | | |
ALT testing | 2020 | 10.00§ | | | |
CBC/creatinine/bilirubin | 2020 | 29.00§ | | | |
Abdominal ultrasonography | 2020 | 135.9 | Statistics Canada 2017 (8) | 68.39 | 271.8 |
HBV treatment and prophylaxis cost, 2020 Can$ |
Treatment (annual) | 2020 | 5770 | Wong et al. 2013 (9) | 3509 | 8031 |
HBV vaccination (children) | 2020 | 11.16* | | 10.92 | 11.40 |
HBV vaccination (adult) | 2020 | 7.44* | | 7.28 | 7.60 |
HBIg | 2020 | 287 | Lapointe-Shaw 2021 (10) | 230 | 344 |
Annual health state cost, 2020 Can$ |
Chronic HBV | 2020 | 1150 | Health Management Branch 2009 (11) | 1048 | 1341 |
Compensated cirrhosis | 2020 | 2517 | Health Management Branch 2009 (11) | 2013 | 3760 |
Decompensated cirrhosis | 2020 | 15 113 | Health Management Branch 2009 (11) | 11 184 | 22 059 |
HCC | 2020 | 17 970 | Health Management Branch 2009 (11) | 14 279 | 23 134 |
Liver transplantation | 2020 | 133 346 | Health Management Branch 2009 (11) | 126 969 | 143 801 |
After liver transplantation | 2020 | 51 475 | Health Management Branch 2009 (11) | 45 015 | 62 035 |