Mauri et al. (11); DAPT, NCT00977938; multinational | Multicentre, placebo-controlled, superiority RCT DAPT: 12 mo (5786) v. 30 mo (5862) | ≥ 18 yr, PCI with a DES or BMS | ASA + clopidogrel or prasugrel for 12 mo, then continued DAPT or discontinuation of P2Y12 inhibitor (ASA continued) for 18 mo | 12 mo post-PCI | Co–primary outcomes: cumulative incidence of definite or probable ST and MACCE (composite of death, MI or stroke) |
Valgimigli et al. (10); PRODIGY, NCT00611286; Italy | Multicentre, open-label, superiority RCT DAPT: 6 mo (723) v. 24 mo (725) | ≥ 18 yr; elective, urgent or emergent coronary angioplasty with intended stent implantation; chronic stable CAD or ACS, including non-STEMI and STEMI | ASA + clopidogrel for 6 or 24 mo | 30 d ± 5 d post-PCI | Composite: death of any cause, MI, cerebrovascular accident |
Collet et al. (6); ARCTIC-Interruption, NCT00827411; France | Multicentre, open-label, superiority RCT DAPT: 12 mo (641) v. 18–30 mo (645) | ≥ 18 yr; DES implantation | ASA alone or + clopidogrel or prasugrel | 12 mo post-PCI | Composite: death, MI, ST, stroke, urgent revascularization |
Lee et al. (9); DES-LATE, NCT01186146; Korea | Multicentre, open-label RCT DAPT: 12 mo (2514) v. 24 mo (2531) | ≥ 18 yr; DES implanted ≥ 12 mo before enrollment | ASA alone or ASA + clopidogrel | 12–18 mo post-PCI | Composite: death resulting from cardiac causes, MI, or stroke |
Gilard et al. (7); ITALIC, NCT01476020; multinational | Multicentre, open-label, noninferiority RCT DAPT: 6 mo (926) v. 24 mo (924) | ≥ 18 yr; PCI with a DES for any indication, with the exception of acute MI and treatment of the left main artery, with confirmed nonresistance to ASA | ASA + clopidogrel, prasugrel, or ticagrelor twice daily | During PCI hospitalization | Composite: death, MI, urgent target vessel revascularization, stroke, and major bleeding |
Helft et al. (8); OPTIDUAL, NCT00822536; France | Multicentre, open-label, superiority RCT DAPT: 12 mo (697) v. 18–48 mo (701) | ≥ 18 yr with symptoms of stable angina, silent ischemia, or ACS (unstable angina, non-STEMI, or STEMI) | ASA alone or ASA + clopidogrel | 12 ± 3 mo post-PCI | Composite: death, MI, stroke, major bleeding |
Nakamura et al. (31); NIPPON, NCT01514227; Japan | Multicentre, noninferiority, open-label RCT DAPT: 6 mo (1654) v. 18 mo (1653) | 21–79 yr, with CAD, including acute MI | ASA + clopidogrel or ticlopidine* | During hospitalization for PCI | Composite: all-cause mortality, MI, stroke, major bleeding |