Research
Open Access
Household transmission of SARS-CoV-2 from unvaccinated asymptomatic and symptomatic household members with confirmed SARS-CoV-2 infection: an antibody-surveillance study
Maala Bhatt, Amy C. Plint, Ken Tang, Richard Malley, Anne Pham Huy, Candice McGahern, Jennifer Dawson, Martin Pelchat, Lauren Dawson, Terry Varshney, Corey Arnold, Yannick Galipeau, Michael Austin, Nisha Thampi, Fuad Alnaji, Marc-André Langlois and Roger L. Zemek
April 12, 2022 10 (2) E357-E366; DOI: https://doi.org/10.9778/cmajo.20220026
Maala Bhatt
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MD MScAmy C. Plint
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MD MScKen Tang
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
PhDRichard Malley
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MDAnne Pham Huy
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MDCandice McGahern
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
BAJennifer Dawson
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
PhDMartin Pelchat
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
PhDLauren Dawson
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MScTerry Varshney
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MDCorey Arnold
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
PhDYannick Galipeau
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
BScMichael Austin
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MDNisha Thampi
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MDFuad Alnaji
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MDMarc-André Langlois
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
PhDRoger L. Zemek
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
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