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Research

Early cholecystectomy for acute cholecystitis: a population-based retrospective cohort study of variation in practice

Charles de Mestral, Andreas Laupacis, Ori D. Rotstein, Jeffrey S. Hoch, Barbara Haas, David Gomez, Brandon Zagorski and Avery B. Nathens
May 16, 2013 1 (2) E62-E67; DOI: https://doi.org/10.9778/cmajo.20130001
Charles de Mestral
1Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont.
3Institute for Clinical Evaluative Sciences, Toronto, Ont.
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Andreas Laupacis
2Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, Ont.
3Institute for Clinical Evaluative Sciences, Toronto, Ont.
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Ori D. Rotstein
2Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, Ont.
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Jeffrey S. Hoch
2Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, Ont.
3Institute for Clinical Evaluative Sciences, Toronto, Ont.
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Barbara Haas
1Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont.
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David Gomez
1Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont.
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Brandon Zagorski
3Institute for Clinical Evaluative Sciences, Toronto, Ont.
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Avery B. Nathens
1Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont.
2Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, Ont.
3Institute for Clinical Evaluative Sciences, Toronto, Ont.
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    Figure 1:

    Selection of patients and hospitals.

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    Figure 2:

    Rate of early cholecystectomy across hospitals among (A) all included patients (n = 24 437 at 106 hospitals) and (B) young healthy patients (< 50 yr, in the lowest comorbidity quartile and with uncomplicated disease [without concurrent biliary tract obstruction or pancreatitis]; n = 2894 at 102 hospitals).

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    Table 1: Multilevel multivariable logistic regression of the association between patient and hospital characteristics and undergoing early cholecystectomy (within 7 d of presentation to an emergency department)
    CharacteristicAdjusted OR (99% CI)*
    Patient
    Age, yr
    18–35Ref
    36–500.92 (0.81–1.05)
    51–650.69 (0.61–0.79)
    66–800.46 (0.40–0.53)
    > 800.21 (0.18–0.25)
    Male sex0.87 (0.80–0.95)
    Income quintile
    1 (lowest)Ref
    20.98 (0.87–1.10)
    30.93 (0.82–1.05)
    41.06 (0.94–1.21)
    51.12 (0.98–1.27)
    Comorbidity index quartile
    1 (lowest)Ref
    20.90 (0.80–1.01)
    30.89 (0.79–1.00)
    40.67 (0.60–0.75)
    Common bile duct obstruction0.41 (0.36–0.47)
    Pancreatitis1.14 (0.94–1.37)
    Hospital
    Annual volume of acute cholecystitis admissions (quartile)
    5–170.53 (0.35–0.78)
    18–390.67 (0.52–0.87)
    40–650.84 (0.72–0.97)
    66–164Ref
    After-hours operating room use† (quartile)
    1 (lowest)0.97 (0.72–1.30)
    20.84 (0.66–1.07)
    30.79 (0.64–0.97)
    4Ref
    Annual volume of elective cholecystectomies (quartile)
    0–741.02 (0.63–1.63)
    75–1591.15 (0.82–1.60)
    160–2791.11 (0.91–1.35)
    280–905Ref
    Academic teaching hospital0.71 (0.27–1.85)

    Note: CI = confidence interval, OR = odds ratio, Ref = reference.
*All listed covariates were included in a multivariable model that also accounted for the nonindependence of patients admitted to the same hospital.
†Ratio of total after-hours operative cases (for all surgical specialties) divided by the number of all-cause emergency department visits.

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    Early cholecystectomy for acute cholecystitis: a population-based retrospective cohort study of variation in practice
    Charles de Mestral, Andreas Laupacis, Ori D. Rotstein, Jeffrey S. Hoch, Barbara Haas, David Gomez, Brandon Zagorski, Avery B. Nathens
    May 2013, 1 (2) E62-E67; DOI: 10.9778/cmajo.20130001

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    Early cholecystectomy for acute cholecystitis: a population-based retrospective cohort study of variation in practice
    Charles de Mestral, Andreas Laupacis, Ori D. Rotstein, Jeffrey S. Hoch, Barbara Haas, David Gomez, Brandon Zagorski, Avery B. Nathens
    May 2013, 1 (2) E62-E67; DOI: 10.9778/cmajo.20130001
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