Self-sacrificial MOFs for ultra-long controlled release of bisphosphonate anti-osteoporotic drugs

M Vassaki, KE Papathanasiou… - Chemical …, 2020 - pubs.rsc.org
In this paper we report drug delivery systems that are based on phosphonate MOFs. These
employ biologically-acceptable metal ions (eg Ca2+ and Mg2+) and several anti …

Effectiveness of oral bisphosphonates in reducing fracture risk among oral glucocorticoid users: three matched cohort analyses

MA Amiche, LE Lévesque, T Gomes… - Journal of Bone and …, 2018 - academic.oup.com
The benefit of oral bisphosphonates in reducing fracture risk in glucocorticoid‐induced
osteoporosis is controversial. We aimed to estimate the effectiveness of oral …

Time trends in oral bisphosphonate initiation in Ontario, Canada over 20 years reflect drug policy and healthcare delivery changes

KN Hayes, JK Ban, G Athanasiadis, AM Burden… - Osteoporosis …, 2019 - Springer
Characteristics of patients starting oral bisphosphonate therapy changed over time,
reflecting trends in osteoporosis management (eg, new drugs to market), and general …

Brand and generic use of inhalation medication and frequency of switching in children and adults: a population-based cohort study

M Engelkes, JC van Blijderveen, JA Overbeek… - Journal of …, 2018 - Taylor & Francis
Background: The expiration of patents of brand inhalation medications and the ongoing
pressure on healthcare budgets resulted in a growing market for generics. Aim: To study the …

Urban–rural differences in the uptake of new oral bisphosphonate formulations

R Jandoc, M Mamdani, LE Lévesque… - Archives of …, 2016 - Springer
We identified significantly slower uptake, and consistently lower proportions of new oral
bisphosphonate formulations dispensed in rural regions compared to urban regions of …

Medication persistence, duration of treatment, and treatment-switching patterns among Canadian patients taking once-daily extended-release methylphenidate …

L Park-Wyllie, J Van Stralen, D Almagor… - Clinical Therapeutics, 2016 - Elsevier
Purpose We conducted a retrospective cohort study to compare medication use patterns of a
long-acting extended-release methylphenidate (Osmotic Release Oral System [OROS®] …

[BOOK][B] Oral Glucocorticoids: Fracture Risk and Benefit of Osteoporosis Pharmacotherapy

MA Amiche - 2017 - search.proquest.com
Oral glucocorticoids are potent anti-inflammatory and immunosuppressant agents used to
treat and control several conditions. However, oral glucocorticoid exposure leads to an …

Understanding Patterns and Estimating Relative Effects of Long-term Bisphosphonate Therapy and Drug Holidays

KN Hayes - 2021 - search.proquest.com
Osteoporosis is a disease of low bone mass that causes debilitating fractures. Oral
bisphosphonates (alendronate, risedronate, and etidronate) are first-line therapy for …