Summary 415 million people live with diabetes worldwide, and an estimated 193 million
people have undiagnosed diabetes. Type 2 diabetes accounts for more than 90% of patients …

Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

Patients with diabetes mellitus have> 2× the risk for developing heart failure (HF; HF with
reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular …

Importance There is substantial uncertainty about optimal glycemic control in older adults
with type 2 diabetes mellitus. Observations Four large randomized clinical trials (RCTs) …

Importance The presence of preexisting type 1 or type 2 diabetes in pregnancy increases
the risk of adverse maternal and neonatal outcomes, such as preeclampsia, cesarean …

Diabetes mellitus is a major risk factor for coronary heart disease (CHD). The major form of
diabetes mellitus is type 2 diabetes mellitus (T2D), which is thus largely responsible for the …

Obesity is a worldwide growing problem. When confronted with obesity, many health care
providers focus on direct treatment of the consequences of adiposity. We plead for adequate …

Change 2: On the basis of current data, the various risk factors and their structured
assessment (including the increasing importance of fatty liver) for the development of …

Since their introduction in clinical practice in the 1950's, Sulfonylureas (SUs) have remained
the main-stay of pharmacotherapy in the management of type 2 diabetes. Despite their well …

Objective To assess whether adding or switching to sulfonylureas is associated with an
increased risk of myocardial infarction, ischaemic stroke, cardiovascular death, all cause …