BACKGROUND AND OBJECTIVE: Health care use of children with medical complexity (CMC),
such as those with neurologic impairment or other complex chronic conditions (CCCs) …

Objective To examine the risk of new onset diabetes among patients treated with different
HMG-CoA reductase inhibitors (statins). Design Population based cohort study with time to …

Purpose Most women diagnosed with breast cancer are younger than 65 years of age.
Population-based studies on cancer therapy–related cardiotoxicity have focused on older women…

Background Unplanned hospital readmissions are common, expensive and often preventable.
Strategies designed to reduce readmissions should target patients at high risk. The …

Background The use of opioids for noncancer pain is widespread, and more than 16,000 die
of opioid-related causes in the United States annually. The patients at greatest risk of death …

Background Use of opioids may predispose drivers to road trauma, yet the effect of opioid
dose on this association is unknown. Methods We conducted a population-based nested case-…

RESEARCH Page 1 RESEARCH Levothyroxine dose and risk of fractures in older adults:
nested case-control study Marci R Turner, medical resident,1 Ximena Camacho, analyst,2 …

Background The increased use of opioid analgesics, sedative hypnotics and stimulants,
coupled with the associated risks of overdose have raised concerns around the inappropriate …

Background Home care is integral to enabling older adults to delay or avoid long-term care (LTC)
admission. To date, there is little population-based data about gender differences in …

Background Myocardial infarction mortality has declined since the 1970s, but contemporary
drivers of this trend remain unexplained. The aim of this study was to compare the …