Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

…, L Lu, DB Lewis, R Tibshirani, G Sherlock, WC Chan… - Nature, 2000 - nature.com
Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma,
is clinically heterogeneous: 40% of patients respond well to current therapy and have …

[HTML][HTML] Tumor-associated macrophages and survival in classic Hodgkin's lymphoma

…, JM Connors, LM Staudt, WC Chan… - … England Journal of …, 2010 - Mass Medical Soc
Background Despite advances in treatments for Hodgkin's lymphoma, about 20% of
patients still die from progressive disease. Current prognostic models predict the outcome of …

Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray

…, LM Staudt, JM Connors, JO Armitage, WC Chan - Blood, 2004 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) can be divided into prognostically important
subgroups with germinal center B-cell–like (GCB), activated B-cell–like (ABC), and type 3 gene …

[PDF][PDF] BCL2 Expression Is a Prognostic Marker for the Activated B-Cell–Like Type of Diffuse Large B-Cell Lymphoma

…, JO Armitage, LM Staudt, WC Chan - Journal of Clinical …, 2006 - researchgate.net
Background The role of BCL2 as a predictor of survival in diffuse large B-cell lymphoma (DLBCL)
is controversial. DLBCL is heterogeneous, and the expression of BCL2 is variable …

Peripheral T cell lymphomas: from the bench to the clinic

…, LV Cappelli, A Broccoli, PL Zinzani, WC Chan… - Nature Reviews …, 2020 - nature.com
Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of orphan neoplasms.
Despite the introduction of anthracycline-based chemotherapy protocols, with or without …

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

…, RR Tubbs, JR Cook, DD Weisenburger, WC Chan… - Nature, 2010 - nature.com
A role for B-cell-receptor (BCR) signalling in lymphomagenesis has been inferred by studying
immunoglobulin genes in human lymphomas 1 , 2 and by engineering mouse models 3 , …

Oncogenically active MYD88 mutations in human lymphoma

…, RR Tubbs, JR Cook, DD Weisenburger, WC Chan… - Nature, 2011 - nature.com
The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) remains
the least curable form of this malignancy despite recent advances in therapy 1 . Constitutive …

Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma

…, ES Jaffe, J Delabie, EB Smeland, RI Fisher, WC Chan… - Science, 2008 - science.org
Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma.
In the least curable (ABC) subtype of DLBCL, survival of the malignant cells is dependent …

Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

…, RR Tubbs, JR Cook, DD Weisenburger, WC Chan… - Nature, 2012 - nature.com
Burkitt’s lymphoma (BL) can often be cured by intensive chemotherapy, but the toxicity of
such therapy precludes its use in the elderly and in patients with endemic BL in developing …

Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma

…, J Armitage, J Vose, WC Chan… - Blood, The Journal …, 2014 - ashpublications.org
Peripheral T-cell lymphoma (PTCL) encompasses a heterogeneous group of neoplasms with
generally poor clinical outcome. Currently 50% of PTCL cases are not classifiable: PTCL-…