Background Myocardial injury after non-cardiac surgery (MINS) increases the risk of
cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran …

Importance The longer-term effects of therapies for the treatment of critically ill patients with
COVID-19 are unknown. Objective To determine the effect of multiple interventions for …

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor
clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-…

Background: Clinical data on patients admitted to hospital with coronavirus disease 2019 (COVID-19)
provide clinicians and public health officials with information to guide practice and …

Importance The efficacy of antiplatelet therapy in critically ill patients with COVID-19 is uncertain.
Objective To determine whether antiplatelet therapy improves outcomes for critically ill …

OBJECTIVES We carried out a pilot randomized controlled study to determine the feasibility
of a large trial evaluating the impact of colchicine versus placebo on postoperative atrial …

Importance The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.
Objective To determine whether vitamin C improves outcomes for patients with COVID-19. …

Background The 3 Wishes Project (3WP) is an end-of-life program that honors the dignity of
dying patients by fostering meaningful connections among patients, families, and clinicians. …

Background: The 3 Wishes Project (3WP) promotes a personalized dying experience by
eliciting and facilitating individualized terminal wishes for patients, families and the clinicians …

Background Individuals vaccinated against severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It …