Background . Septic shock is common and results in significant morbidity and mortality.
Adjunctive treatment with corticosteroids is common, but definitive data are lacking. We aimed to …

Objective: Some studies suggest better outcomes with macrolide therapy for critically ill patients
with community-acquired pneumonia. To further explore this, we performed a systematic …

Background. Macrolides are used to treat pneumonia despite increasing antimicrobial resistance.
However, the immunomodulatory properties of macrolides may have a favorable effect …

Background The efficacy of interleukin-6 receptor antagonists in critically ill patients with
coronavirus disease 2019 (Covid-19) is unclear. Methods We evaluated tocilizumab and …

Background: The role of remdesivir in the treatment of patients in hospital with COVID-19
remains ill defined in a global context. The World Health Organization Solidarity randomized …

Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …

The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–driven
coronavirus disease 2019 (COVID-19) has caused unprecedented human death and …

Background Community-acquired pneumonia (CAP) is a common and serious condition.
Combined with influenza, pneumonia is the most frequent cause of infection-related death …

OBJECTIVES: Nosocomial Gram-negative bacteremia in the critically ill is associated with
significant morbidity and mortality. This study provides epidemiological and antimicrobial …

ACE (angiotensin-converting enzyme)-2 as the target for SARS-CoV-2 also negatively
regulates the renin-angiotensin system. Pathological activation of ADAM17 (A disintegrin and …