Inhibiting signal transduction induced by inflammatory cytokines offers a new approach for
the treatment of autoimmune diseases such as rheumatoid arthritis. Kinase inhibitors have …

We describe here the existence of a heregulin-HER3 autocrine loop, and the contribution of
heregulin-dependent, HER2-mediated HER3 activation to gefitinib insensitivity in non-small …

… Babul, M. Chipman, MDCusimano, JRBrubacher, G. Hunte, and SMFriedman designed and
obtained funding for the study. M. Monro and L. Vernich coordinated the study conduct and …

The major histocompatibility complex class I-restricted cytotoxic T lymphocyte (CTL) response
is important in the clearance of viral infections in humans. After influenza A infection, a …

Background This study examined the impact of transportation infrastructure at intersection
and non-intersection locations on bicycling injury risk. Methods In Vancouver and Toronto, we …

The binding of tumor necrosis factor alpha (TNF-α) to the type-1 TNF receptor (TNFRc1)
plays an important role in inflammation. Despite the clinical success of biologics (antibodies, …

The Apo-1/Fas antigen (CD95) mediates programmed cell death of lymphocytes when bound
by Fas ligand or anti-Apo-1/Fas antibody. In contrast, the CD40 antigen provides a potent …

Purpose: ErbB receptor signaling pathways are important regulators of cell fate, and their
dysregulation, through (epi)genetic alterations, plays an etiologic role in multiple cancers. ErbB …

A new mechanical explant test system was used to study the metabolic response (via
proteoglycan biosynthesis) of mature, weight-bearing canine articular cartilage subjected to static …

Objective Safety concerns deter cycling. The Bicyclists’ Injuries and the Cycling Environment
(BICE) study quantified the injury risk associated with 14 route types, from off-road paths to …