OBJECTIVES: We aimed to systematically review and assess published estimates of the
cost of developing new drugs. METHODS: We sought English language research articles …

Tissue engineering scaffolds require a controlled pore size and structure to host tissue formation.
Supercritical carbon dioxide (scCO2) processing may be used to form foamed scaffolds …

Goodpasture's disease is characterized by rapidly progressive glomerulonephritis, often
accompanied by pulmonary hemorrhage, in association with deposition of antibodies in a linear …

OBJECTIVE: We examined changes in patterns of benzodiazepine use in British Columbia
over a period of increasing evidence of harms associated with long-term use. METHODS: …

Background This paper assesses the agreement between household-level income data
and an area-based income measure, and whether or not discrepancies create meaningful …

Background: The orthopaedic literature contains few studies evaluating the long-term
outcomes of unstable pelvic fractures in skeletally immature patients. The purpose of this study …

PURPOSE: To estimate the prevalence of posttraumatic stress disorder (PTSD) and
depression among hand-injured patients and assess the impact of these disorders on general …

Purpose To describe trends, patterns, and determinants of prescription drug use during
pregnancy and postpartum. Methods This is a retrospective, population-based study of all …

" Canadians spent almost $23-billion on prescription drugs at retail pharmacies in 2012/13–or
over $650 per capita. That is a lot of money. However, after adjusting for general inflation, …

Polypharmacy is growing in Canada, along with adverse drug events and drug-related costs.
Part of the solution may be deprescribing, the planned and supervised process of dose …