The Akt isoforms are present at distinct subcellular locations

SA Santi, H Lee - American Journal of Physiology-Cell …, 2010 - journals.physiology.org
Akt is involved in the regulation of diverse cellular functions such as cell proliferation, energy
metabolism, and apoptosis. Although three Akt isoforms are known, the function of each …

[HTML][HTML] Role of autophagy and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cells

B Guo, A Tam, SA Santi, AM Parissenti - BMC cancer, 2016 - Springer
Background The roles and mechanisms involved in starvation-induced autophagy in
mammalian cells have been extensively studied. However, less is known about the potential role …

[HTML][HTML] Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells

SA Santi, H Lee - PLoS One, 2011 - journals.plos.org
Background Akt/PKB is a promising anticancer therapeutic target, since abnormally elevated
Akt activity is directly correlated to tumor development, progression, poor prognosis and …

[HTML][HTML] Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species

…, K Venkataraman, D Brabant-Kirwan, SA Santi… - Cells, 2023 - mdpi.com
Candidiasis is a highly pervasive infection posing major health risks, especially for
immunocompromised populations. Pathogenic Candida species have evolved intrinsic and acquired …

Access to palliative care for cancer patients living in a northern and rural environment in Ontario, Canada: the effects of geographic region and rurality on end-of-life …

MSC Conlon, JM Caswell, SA Santi… - Clinical Medicine …, 2019 - journals.sagepub.com
Background: Access to palliative care has been associated with improving quality of life and
reducing the use of potentially aggressive end-of-life care. However, many challenges and …

The Akt isoforms, their unique functions and potential as anticancer therapeutic targets

SA Santi, AC Douglas, H Lee - 2010 - degruyter.com
Akt (also known as protein kinase B or PKB) is the major downstream nodal point of the
PI3K signaling pathway. This pathway is a promising anticancer therapeutic target, because …

[HTML][HTML] Rates of smoking cessation at 6 and 12 months after a clinical tobacco smoking cessation intervention in head and neck cancer patients in Northern Ontario …

SA Santi, MSC Conlon, ML Meigs, SM Davidson… - Current …, 2022 - mdpi.com
Smoking during cancer treatment is associated with reduced treatment response and
cancer recurrence in patients with tobacco-related cancers. The purpose of this study was to …

A case–control study of breast cancer risk in nurses from Northeastern Ontario, Canada

SA Santi, ML Meigs, Y Zhao, MA Bewick… - Cancer Causes & …, 2015 - Springer
Purpose Previously published findings have documented increased breast cancer risks
associated with the nursing profession. The aim of the present study was to assess whether an …

Impact of comprehensive hospice palliative care on end-of-life care: a propensity-score–matched retrospective observational study

…, A Knight, B Ballantyne, SA Santi… - … Open Access Journal, 2019 - cmajopen.ca
Background: Access to hospice palliative care may improve quality of life, reduce the use of
potentially aggressive end-of-life care and allow for death to occur outside of an acute care …

[HTML][HTML] A Comparison Between the Rates of Radiation Oncologist and Urologist Consultations in Men Diagnosed With Prostate Cancer in Northern Ontario, Canada

SA Santi, JM Caswell, AS Beruar, RG Carlson… - Advances in Radiation …, 2023 - Elsevier
Purpose Recommendations from Cancer Care Ontario stress the importance of multidisciplinary
care from radiologists and urologists for prostate cancer treatment. The present study …