Importance Harms and benefits of opioids for chronic noncancer pain remain unclear.
Objective To systematically review randomized clinical trials (RCTs) of opioids for chronic …

Importance The discontinuation of randomized clinical trials (RCTs) raises ethical concerns
and often wastes scarce research resources. The epidemiology of discontinued RCTs, …

Background Activity-based funding (ABF) of hospitals is a policy intervention intended to re-shape
incentives across health systems through the use of diagnosis-related groups. Many …

Background and Purpose— Central poststroke pain is a chronic neuropathic disorder that
follows a stroke. Current research on its management is limited, and no review has evaluated …

Objective To investigate the planning of subgroup analyses in protocols of randomised
controlled trials and the agreement with corresponding full journal publications. Design Cohort of …

Clinical investigators are increasingly testing treatments that have the primary benefit of
decreased burden or harms relative to an existing standard. The goal of the resulting …

Introduction Patients’ expectations regarding their prognosis has been shown to affect
recovery. We completed a systematic review to identify measures that assess patients’ …

The Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT)
has recommended that trialists evaluating treatments for chronic pain should consider …

Objectives To determine the proportion of pediatric randomized controlled trials (RCTs) that
are prematurely discontinued, examine the reasons for discontinuation, and compare the …

Objectives: Randomized clinical trials that enroll patients in critical or emergency care (acute
care) setting are challenging because of narrow time windows for recruitment and the …