Background Clozapine effectiveness in the treatment of refractory schizophrenia has been
sustained by published evidence in the last two decades, despite the introduction of safer …

Background: Sodium–glucose cotransporter-2 (SGLT-2) inhibitors could increase the risk
for diabetic ketoacidosis (DKA). Objective: To assess whether SGLT-2 inhibitors, compared …

Objective To compare the risk of cardiovascular events between sodium glucose cotransporter
2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors among people with …

Objective: To report the prescribing of antipsychotics to the youth population of the Canadian
province of Manitoba during the course of a decade. Methods: Use of antipsychotics in …

Background: The coronavirus disease 2019 (COVID-19) pandemic and public health measures
that took place have led to concerns regarding mental health and receipt of psychotropic …

… Contributors: Silvia Alessi-Severini and James M. Bolton … Silvia Alessi-Severini wrote the
paper, Matthew Dahl … (James Bolton and Silvia Alessi-Severini). Additional investigator support …

Background Prenatal antibiotic exposure induces changes in infants’ gut microbiota
composition and is suggested as a possible contributor in the development of autism spectrum …

Background Around 30% of the population will experience herpes zoster (HZ), 10% of whom
develop postherpetic neuralgia (PHN). Together, these illnesses produce a significant …

Methods This population-based study received ethics approval from the Research Ethics
Board of the University of Manitoba. The protocol was also approved by the Manitoba Health …

OBJECTIVE Reports of amputations associated with sodium–glucose cotransporter 2 (SGLT2)
inhibitors have been inconsistent. We aimed to compare the risk of below-knee …