Background There is substantial variability in the perioperative administration of aspirin in
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …

Importance Little is known about the relationship between perioperative high-sensitivity
troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac …

Background We previously reported that there was no significant difference at 30 days or at
1 year in the rate of the composite outcome of death, stroke, myocardial infarction, or renal …

Background Marked activation of the sympathetic nervous system occurs during and after
noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may …

Background Cardiopulmonary bypass initiates a systemic inflammatory response syndrome
that is associated with postoperative morbidity and mortality. Steroids suppress inflammatory …

Background Myocardial injury after non-cardiac surgery (MINS) increases the risk of
cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran …

Background Observational studies have suggested that accelerated surgery is associated
with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed …

BACKGROUND: Among adults undergoing contemporary noncardiac surgery, little is
known about the frequency and timing of death and the associations between perioperative …

Background In non-surgical settings, covert stroke is more common than overt stroke and is
associated with cognitive decline. Although overt stroke occurs in less than 1% of adults after …

Background: Preliminary data suggest that preoperative N-terminal pro–B-type natriuretic
peptide (NT-proBNP) may improve risk prediction in patients undergoing noncardiac surgery. …