Background Semaglutide, a glucagon-like peptide-1 receptor agonist, has been shown to
reduce the risk of adverse cardiovascular events in patients with diabetes. Whether …

▪ Abstract It is widely but incorrectly believed that the t-test and linear regression are valid
only for Normally distributed outcomes. The t-test and linear regression compare the mean of …

Surrogate end-point biomarkers (SEBs) have become widely used in short-term cancer
chemoprevention trials in place of cancer end points. This paper discusses criteria relevant to the …

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Background Degludec is an ultralong-acting, once-daily basal insulin that is approved for
use in adults, adolescents, and children with diabetes. Previous open-label studies have …

Background Over 1000 mutations of the cystic fibrosis transmembrane conductance regulator
gene (CFTR) that cause cystic fibrosis have been identified. We examined the effect of …

ContextRenal failure places people at particularly high risk of hip fracture. However, the possible
differential impact of dialysis and renal transplantation on this risk is not well understood…

Context Faster magnetic resonance imaging (MRI) scanning has made MRI a potential cost-effective
replacement for radiographs for patients with low back pain. However, whether …

On November 6, 2020, a US Food and Drug Administration (FDA) advisory committee
reviewed issues related to the efficacy and safety of aducanumab, a human IgG1 anti-Aβ …

Purpose: Indwelling urinary catheters are implicated in most cases of nosocomial urinary tract
infection. Silver-coating of catheters may reduce the risk of these infections; however, trials …