Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies: the PRISMA-DTA statement
…, MMG Leeflang, P Macaskill, JB Reitsma, R Rodin… - Jama, 2018 - jamanetwork.com
Importance Systematic reviews of diagnostic test accuracy synthesize data from primary
diagnostic studies that have evaluated the accuracy of 1 or more index tests against a reference …
diagnostic studies that have evaluated the accuracy of 1 or more index tests against a reference …
Aging and neurodegeneration are associated with increased mutations in single human neurons
It has long been hypothesized that aging and neurodegeneration are associated with
somatic mutation in neurons; however, methodological hurdles have prevented testing this …
somatic mutation in neurons; however, methodological hurdles have prevented testing this …
Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network
BACKGROUND Elucidating the genetic architecture of neuropsychiatric disorders remains
a major scientific and medical challenge. Emerging genomic technologies now permit the …
a major scientific and medical challenge. Emerging genomic technologies now permit the …
Risk of severe outcomes among patients admitted to hospital with pandemic (H1N1) influenza
A Campbell, R Rodin, R Kropp, Y Mao, Z Hong… - CmAJ, 2010 - Can Med Assoc
Background: We describe the disease characteristics and outcomes, including risk factors
for admission to intensive care unit (ICU) and death, of all patients in Canada admitted to …
for admission to intensive care unit (ICU) and death, of all patients in Canada admitted to …
The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing
We characterize the landscape of somatic mutations—mutations occurring after fertilization—in
the human brain using ultra-deep (~250×) whole-genome sequencing of prefrontal …
the human brain using ultra-deep (~250×) whole-genome sequencing of prefrontal …
Risk of sexual transmission of human immunodeficiency virus with antiretroviral therapy, suppressed viral load and condom use: a systematic review
… Contributors: Rachel Rodin conceptualized and oversaw this project in response to the …
Rachel Rodin and Jennifer LeMessurier designed the project with input from Gregory …
Rachel Rodin and Jennifer LeMessurier designed the project with input from Gregory …
Linked-read analysis identifies mutations in single-cell DNA-sequencing data
Whole-genome sequencing of DNA from single cells has the potential to reshape our
understanding of mutational heterogeneity in normal and diseased tissues. However, a major …
understanding of mutational heterogeneity in normal and diseased tissues. However, a major …
Accurate detection of mosaic variants in sequencing data without matched controls
Detection of mosaic mutations that arise in normal development is challenging, as such
mutations are typically present in only a minute fraction of cells and there is no clear matched …
mutations are typically present in only a minute fraction of cells and there is no clear matched …
Managing conflicts of interest in the development of health guidelines
E50 CMAJ| JANUARY 11, 2021| VOLUME 193| ISSUE 2 researchers who advance scholarship
in guideline development methods, dissemination and implementation. Finally, COIs can …
in guideline development methods, dissemination and implementation. Finally, COIs can …
Comprehensive identification of somatic nucleotide variants in human brain tissue
…, JB Moldovan, R Narurkar, MT Oetjens, RE Rodin… - Genome biology, 2021 - Springer
Background Post-zygotic mutations incurred during DNA replication, DNA repair, and other
cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of …
cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of …
