For millennia, selective breeding, on the basis of biparental mating, has led to the successful
improvement of plants and animals to meet societal needs 1 . At a molecular level, DNA …

Fermentation-based bioprocesses rely extensively on strain improvement for commercialization.
Whole-cell biocatalysts are commonly limited by low tolerance of extreme process …

This article is an updated report of a symposium held at the June 2000 annual meeting of
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …

Developmental pathologies may result from endogenous or xenobiotic-enhanced formation
of reactive oxygen species (ROS), which oxidatively damage cellular macromolecules and/…

The teratogenicity of many xenobiotics is thought to depend at least in part upon their
bioactivation by embryonic cytochromes P450, prostaglandin H synthase (PHS) and …

Background and Aims: Biosimilar infliximab CT-P13 offers the potential for large drug
acquisition cost savings. However, there are limited published data regarding its efficacy, safety, …

Current guidelines suggest that disseminated Mycobacterium avium complex (MAC) infection
be treated with a macrolide plus ethambutol or rifabutin or both. From 1993 to 1996, 198 …

Double-strand breaks (DSBs) can be repaired by homologous recombination (HR) in
mammalian cells, often resulting in gene conversion. RAD51 functions with RAD52 and other …

All humans receive some radiation exposure and the risk for radiation-induced cancer at low
doses is based on the assumption that there is a linear non-threshold relationship between …

Valproic acid, a commonly used antiepileptic agent, is associated with a 1 to 2% incidence
of neural tube defects when taken during pregnancy; however, the molecular mechanism by …