Current guidelines identify people with chronic kidney disease (CKD) as being at high risk
for cardiovascular and all-cause mortality. Because as many as 19 million Americans may …

Importance Numerous glucose-lowering drugs are used to treat type 2 diabetes. Objective
To estimate the relative efficacy and safety associated with glucose-lowering drugs including …

Context The current staging system for chronic kidney disease is based primarily on estimated
glomerular filtration rate (eGFR) with lower eGFR associated with higher risk of adverse …

Background: Guidelines recommend that patients with heart failure receive β-blockers in
doses used in the trials that have proven their efficacy. Although the adverse effects of β-…

Background. The efficacy of tenofovir disoproxil fumarate (TDF) as part of combination
antiretroviral treatment (ART) has been demonstrated in several randomized, controlled trials. …

Background: Even with optimal pharmacotherapy, symptomatic heart failure is associated
with substantial morbidity and mortality. Purpose: To determine the efficacy and safety of …

Statins frequently are used to prevent cardiovascular events. Several recent studies suggest
that statins also may have renal benefits, although this is controversial. This systematic …

ContextContrast-induced nephropathy is associated with significant economic and clinical
consequences, including prolonged hospitalization, the requirement for dialysis, and an …

Abstract Information on common causes of death in people with CKD is limited. We hypothesized
that, as eGFR declines, cardiovascular mortality and mortality from infection account for …

Context Acute renal failure requiring dialytic support is associated with a high risk of mortality
and substantial morbidity. Objectives To summarize current evidence guiding provision of …