Background Emergence delirium has been investigated in several clinical trials. However,
no reliable and valid rating scale exists to measure this phenomenon in children. Therefore, …

Background Sevoflurane is a new volatile anesthetic with physical properties that should make
it suitable for anesthesia (MAC of sevoflurane on oxygen alone and in 60% nitrous oxide,(…

Background To investigate dexmedetomidine in children, the authors performed an open-label
study of the pharmacokinetics and pharmacodynamics of dexmedetomidine. Methods …

Although intravenous thrombolysis increases the probability of a good functional outcome in
carefully selected patients with acute ischemic stroke, a substantial proportion of patients …

Anemia may worsen neurological outcomes following traumatic brain injury (TBI) by undefined
mechanisms. We hypothesized that hemodilutional anemia accentuates hypoxic cerebral …

Purpose Genetic testing is routine practice for individuals with unexplained developmental
disabilities and multiple congenital anomalies. However, current testing pathways can be …

Objectives: This study describes the development of a framework for health technology
decisions, for Ontario Health Technology Advisory Committee (OHTAC) in Ontario, Canada.…

Background Specialized multidisciplinary clinics have been shown to reduce mortality in
heart failure (HF). Our objective was to evaluate the cost-effectiveness of this model of care …

Background: The beneficial effects of endovascular treatment with new-generation mechanical
thrombectomy devices compared with intravenous thrombolysis alone to treat acute large-…

Background Radiofrequency thalamotomy and deep brain stimulation are current treatments
for moderate to severe medication‐refractory essential tremor. However, they are invasive …