Background Lifestyle factors have been associated mostly with individual chronic diseases.
We investigated the relationship between lifestyle factors (individual and combined) and the …

PURPOSE We aimed to develop a consensus-based set of core outcomes specifically for
studies in multimorbidity. METHODS We undertook a consensus study following the COS-…

Objective Determine the effectiveness of digital mental health interventions for individuals with
a concomitant chronic disease. Design We conducted a rapid review of systematic reviews…

Gap-junctional communication (GJC) plays a central role in oocyte growth. However, little is
known about the regulation of connexin 43 (Cx43)-based gap-junction channels in cumulus-…

The phosphodiesterase (PDE) family is a group of enzymes that catalyzes the transformation
of cyclic nucleotides into 5′ nucleotides. Based on rodents, the current mammalian model …

Ovarian folliculogenesis is driven by the combined action of endocrine cues and paracrine
factors. The oocyte secretes powerful mitogens, such as growth differentiation factor 9 (GDF9)…

Background Chronic diseases represent a major challenge for health care and social services.
A number of people with chronic diseases require more services due to characteristics …

Background The ovulatory surge of gonadotropins triggers oocyte maturation and rupture of
the ovarian follicle. The resumption of nuclear maturation in the oocyte from the prophase …

Background: Chronic disease prevention and management programs are usually single-disease
oriented. Our objective was to evaluate an intervention that targeted multiple chronic …

Background: The advanced access model was developed 20 years ago and has been
implemented in several countries. We aimed to revise and operationalize the pillars and …