Background The contribution of various risk factors to the burden of stroke worldwide is
unknown, particularly in countries of low and middle income. We aimed to establish the …

Background Although more than 80% of the global burden of cardiovascular disease occurs
in low-income and middle-income countries, knowledge of the importance of risk factors is …

The past decade has witnessed hundreds of reports declaring or refuting genetic association
with putative Alzheimer disease susceptibility genes. This wealth of information has …

Tobacco and alcohol use are leading causes of mortality that influence risk for many complex
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …

Background Stroke is a leading cause of death and disability, especially in low-income and
middle-income countries. We sought to quantify the importance of potentially modifiable risk …

Background Angiotensin receptor blockers (ARB) and angiotensin converting enzyme (ACE)
inhibitors are known to reduce proteinuria. Their combination might be more effective than …

In an effort to pinpoint potential genetic risk factors for schizophrenia, research groups worldwide
have published over 1,000 genetic association studies with largely inconsistent results. …

Background Cardiovascular disease rates vary greatly between ethnic groups in Canada. To
establish whether this variation can be explained by differences in disease risk factors and …

Background Whether lipoproteins are better markers than lipids and lipoproteins for
coronary heart disease is widely debated. Our aim was to compare the apolipoproteins and …

Background The optimal range of sodium intake for cardiovascular health is controversial.
Methods We obtained morning fasting urine samples from 101,945 persons in 17 countries …