A consensus meeting was convened by the Initiative on Methods, Measurement, and Pain
Assessment in Clinical Trials (IMMPACT) to provide recommendations for interpreting clinical …

The multidimensional nature of chronic pain is not reflected by definitions based solely on
pain duration, resulting in high prevalence estimates limiting effective policy development. The …

Background Which medication, if any, to use to prevent the headache of pediatric migraine
has not been established. Methods We conducted a randomized, double-blind, placebo-…

There has been an increase in the number of chronic pain clinical trials in which the treatments
being evaluated did not differ significantly from placebo in the primary efficacy analyses …

There is tremendous interpatient variability in the response to analgesic therapy (even for
efficacious treatments), which can be the source of great frustration in clinical practice. This …

National Pain Strategy population research objectives include: estimating chronic pain
prevalence, studying pain treatment with electronic health care data, and developing metrics to …

A number of pharmacologic treatments examined in recent randomized clinical trials (RCTs)
have failed to show statistically significant superiority to placebo in conditions in which their …

This document reports the consensus of an interdisciplinary panel of research and clinical
experts charged with reviewing the use of opioids for chronic noncancer pain (CNCP) and …

Importance Despite epidemic rates of addiction and death from prescription opioids in the
United States, suggesting the importance of providing alternatives to opioids in the treatment …

Although chronic pain is one of the most important medical problems facing society, there
has been very limited progress in the development of novel therapies for this condition. Here, …