User profiles for Lena Nguyen
 | Lena H. NguyenUniversity of Texas at Dallas Verified email at utdallas.edu Cited by 351 |
Effectiveness of a fourth dose of covid-19 mRNA vaccine against the omicron variant among long term care residents in Ontario, Canada: test negative design study
R Grewal, SA Kitchen, L Nguyen, SA Buchan… - Bmj, 2022 - bmj.com
Objectives To estimate the marginal effectiveness of a fourth versus third dose and the
vaccine effectiveness of mRNA covid-19 vaccines BNT162b2 and mRNA-1273 against any …
vaccine effectiveness of mRNA covid-19 vaccines BNT162b2 and mRNA-1273 against any …
[HTML][HTML] Effectiveness of mRNA COVID-19 vaccine booster doses against Omicron severe outcomes
R Grewal, L Nguyen, SA Buchan, SE Wilson… - nature …, 2023 - nature.com
We estimated the effectiveness of booster doses of monovalent mRNA COVID-19 vaccines
against Omicron-associated severe outcomes among adults in Ontario, Canada. We used a …
against Omicron-associated severe outcomes among adults in Ontario, Canada. We used a …
mTOR hyperactivity levels influence the severity of epilepsy and associated neuropathology in an experimental model of tuberous sclerosis complex and focal cortical …
Tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) are focal malformations
of cortical development (FMCDs) that are highly associated with intractable epilepsy. TSC …
of cortical development (FMCDs) that are highly associated with intractable epilepsy. TSC …
mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia
LH Nguyen, AL Brewster, ME Clark… - …, 2015 - Wiley Online Library
Objective Hyperactivation of the mechanistic target of rapamycin (m TOR ; also known as
mammalian target of rapamycin) pathway has been demonstrated in human cortical dysplasia ( …
mammalian target of rapamycin) pathway has been demonstrated in human cortical dysplasia ( …
[HTML][HTML] Convergent and divergent mechanisms of epileptogenesis in mTORopathies
Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) due to mutations
in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a spectrum of …
in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a spectrum of …
Effectiveness of mRNA COVID-19 Monovalent and Bivalent Vaccine Booster Doses Against Omicron Severe Outcomes Among Adults Aged≥ 50 Years in Ontario …
R Grewal, SA Buchan, L Nguyen… - The Journal of …, 2024 - academic.oup.com
We estimated the effectiveness of booster doses of monovalent and bivalent mRNA COVID-19
vaccines against Omicron-associated severe outcomes among adults aged ≥50 years in …
vaccines against Omicron-associated severe outcomes among adults aged ≥50 years in …
[HTML][HTML] Plakophilin 2 gene therapy prevents and rescues arrhythmogenic right ventricular cardiomyopathy in a mouse model harboring patient genetics
…, Y Liang, A Do, TM Wang, L Nguyen… - Nature Cardiovascular …, 2023 - nature.com
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a fatal genetic heart disease
characterized by cardiac arrhythmias, in which fibrofatty deposition leads to heart failure, with …
characterized by cardiac arrhythmias, in which fibrofatty deposition leads to heart failure, with …
Vaccine effectiveness of BNT162b2 against delta and omicron variants in adolescents
SA Buchan, L Nguyen, SE Wilson, SA Kitchen… - …, 2022 - publications.aap.org
Methods We conducted a test-negative design study among individuals aged 12 to 17 years
and SARS-CoV-2 tested (by real-time reverse transcription polymerase chain reaction) …
and SARS-CoV-2 tested (by real-time reverse transcription polymerase chain reaction) …
The mTOR pathway genes mTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
Brain somatic mutations in various components of the mTOR complex 1 (mTORC1) pathway
have emerged as major causes of focal malformations of cortical development and …
have emerged as major causes of focal malformations of cortical development and …
Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice
The causative link between focal cortical malformations (FCMs) and epilepsy is well
accepted, especially among patients with focal cortical dysplasia type II (FCDII) and tuberous …
accepted, especially among patients with focal cortical dysplasia type II (FCDII) and tuberous …