Background Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease
worldwide and the leading cause of liver-related morbidity and mortality. We aimed to predict …

Cytokines are molecules secreted by peripheral immune cells, microglia, astrocytes and
neurons in the central nervous system. Peripheral or central inflammation is characterized by an …

Inflammation is an important factor in the pathophysiology of seizure generation and
epileptogenesis. While the role of CNS inflammation is well acknowledged as an important factor in …

Peripheral inflammation leads to a number of centrally mediated physiological and behavioral
changes. The underlying mechanisms and the signaling pathways involved in these …

There are critical postnatal periods during which even subtle interventions can have long-lasting
effects on adult physiology. We asked whether an immune challenge during early …

Peripheral inflammatory diseases are often associated with behavioral comorbidities including
anxiety, depression, and cognitive dysfunction, but the mechanism for these is not well …

Recent evidence indicates that sildenafil may exert some central effects through enhancement
of nitric oxide (NO)‐mediated effects. NO is known to have modulatory effects on seizure …

Non-alcoholic fatty liver disease (NAFLD) is a significant public health concern worldwide
with a complex etiology attributed to behavioural, environmental, and genetic causes. The …

Sickness behaviors, such as fatigue, mood alterations, and cognitive dysfunction, which
result from changes in central neurotransmission, are prevalent in systemic inflammatory …

Nonalcoholic fatty liver disease (NAFLD) is a rising epidemic worldwide and will be the leading
cause of cirrhosis, hepatocellular carcinoma, and liver transplant within the next decade. …