The t (4; 14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplant

…, QL Yi, CI Chen, D Reece, K Chun… - British journal of …, 2004 - Wiley Online Library
The frequency and prognostic relevance of translocations t(11;14) and t(4;14), the most
common translocations involving the immunoglobulin heavy chain (IgH) gene in multiple …

[HTML][HTML] The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations

…, F Spatare, JA Whitlock, SW Scherer, K Chun… - Nature Cancer, 2023 - nature.com
We conducted integrative somatic–germline analyses by deeply sequencing 864 cancer-associated
genes, complete genomes and transcriptomes for 300 mostly previously treated …

Extramedullary infiltrates of AML are associated with CD56 expression, 11q23 abnormalities and inferior clinical outcome

H Chang, J Brandwein, K Chun, B Patterson, B Brien - Leukemia Research, 2004 - Elsevier
We evaluated the frequency and prognostic significance of extramedullary infiltrates (EMI) at
presentation of acute myeloid leukemia (AML) in adult patients. Of 331 cases with de novo …

Associations between the uptake of 111In-DTPA-trastuzumab, HER2 density and response to trastuzumab (Herceptin) in athymic mice bearing subcutaneous human …

…, B Cornelissen, DA Scollard, SJ Done, K Chun… - European journal of …, 2009 - Springer
Purpose The purpose of the study was to investigate the associations between uptake of 111
In-DTPA-trastuzumab, tumour HER2 density and response to trastuzumab (Herceptin) of …

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

…, MD Minden, AC Schuh, RA Wells, H Messner, K Chun… - Blood, 2005 - ashpublications.org
We tested the effects of small-molecule XIAP antagonists based on a polyphenylurea
pharmacophore on cultured acute myelogenous leukemia (AML) cell lines and primary patient …

[HTML][HTML] Src promotes estrogen-dependent estrogen receptor α proteolysis in human breast cancer

…, J Sun, A Seth, C McMahon, K Chun… - The Journal of …, 2007 - Am Soc Clin Investig
Estrogen drives both transcriptional activation and proteolysis of estrogen receptor α (ERα;
encoded by ESR1). Here we observed variable and overlapping ESR1 mRNA levels in 200 …

Progression of myelodysplasia to acute lymphoblastic leukaemia: implications for disease biology

P Disperati, CV Ichim, D Tkachuk, K Chun, AC Schuh… - Leukemia research, 2006 - Elsevier
Myelodysplastic syndrome (MDS) comprises a group of clonal haematopoietic disorders
characterized by peripheral blood cytopenias, bone marrow hypercellularity, and abnormal …

Genetic analysis of patients with the Saethre‐Chotzen phenotype

K Chun, AS Teebi, JH Jung, S Kennedy… - American journal of …, 2002 - Wiley Online Library
Kathy ChunKathy ChunKathy Chun

FGFR2 mutation associated with clinical manifestations consistent with Antley‐Bixler syndrome

K Chun, J Siegel‐Bartelt, D Chitayat… - American journal of …, 1998 - Wiley Online Library
The Antley‐Bixler syndrome (ABS) is a rare syndrome with synostosis of cranial sutures and
elbow joints as minimal diagnostic criteria. The inheritance has been suggested to be …

Disease biology rather than age is the most important determinant of survival of patients≥ 60 years with acute myeloid leukemia treated with uniform intensive therapy

V Gupta, K Chun, QL Yi, M Minden… - … Journal of the …, 2005 - Wiley Online Library
BACKGROUND The objectives of the current study were to evaluate the outcome of patients
≥ 60 years with acute myeloid leukemia (AML) treated uniformly with high‐dose …